Document Detail

Stress, immunity and skin collagen integrity: evidence from animal models and clinical conditions.
MedLine Citation:
PMID:  19523511     Owner:  NLM     Status:  MEDLINE    
The skin is the largest organ of the human body and plays a major role in maintaining homeostasis and protection. As the main component of skin, collagen has a key role in providing integrity and elasticity to this organ. Several factors, including autoimmune disease, aging, and stress, can change the quantity and integrity of skin collagen. These factors impair collagen quality and consequently affect skin function. Stress seems to affect the integrity of skin collagen through glucocorticoid-mediated processes that alter its synthesis and degradation. Glucocorticoids also affect skin quality through modulation of the immune system. This review will briefly present comprehensive data from both animal and human studies delineating processes that modulate alterations in collagen in general, and will treat in more detail the consequences of stress on skin collagen.
V Kahan; M L Andersen; J Tomimori; S Tufik
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-10
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  23     ISSN:  1090-2139     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2009-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1089-95     Citation Subset:  IM    
Department of Psychobiology, Universidade Federal de S??o Paulo (UNIFESP) - S??o Paulo, SP, Brazil.
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MeSH Terms
Aging / immunology
Collagen / immunology*
Glucocorticoids / immunology
Skin / immunology*
Stress, Psychological / immunology*
Reg. No./Substance:
0/Glucocorticoids; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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