| Stress hypertension in monkeys. | |
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MedLine Citation:
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PMID: 2150986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The influence of chronic forelimb immobilization enforcing movement in upright position on blood pressure was studied in monkeys. 2. In the course of 6 months all animals subjected to immobilization became hypertensive due to a parallel increase of systolic and diastolic pressure by about 30%. The hypertension was demonstrable both in awake and anaesthetized animals and persisted even after restitution of a normal movement regime. 3. In the chronic stage (after 15 months), the plasma renin concentration was decreased by 55%, indicating that the renin-angiotensin system activation does not participate in the maintenance of the hypertensive state. The plasma volume was diminished by 18%, while the interstitial fluid volume did not differ significantly from control values. 4. It is concluded that chronic forelimb immobilization in monkeys induces a low-renin hypertension, associated with changes in extracellular fluid compartments resembling the pattern found in the hypovolaemic type of essential hypertension. |
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Authors:
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J Kunes; A N Demin; J Jelínek; K Capek; G S Belkaniya |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Physiologia Bohemoslovaca Volume: 39 ISSN: 0369-9463 ISO Abbreviation: Physiol Bohemoslov Publication Date: 1990 |
Date Detail:
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Created Date: 1991-05-28 Completed Date: 1991-05-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0175317 Medline TA: Physiol Bohemoslov Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 417-23 Citation Subset: IM; S |
Affiliation:
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Institute of Physiology, Czechoslovak Academy of Sciences, Prague. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Blood Volume / physiology Glomerular Filtration Rate / physiology Hypertension / etiology, physiopathology* Immobilization / physiology Macaca mulatta / physiology* Renin / blood Stress, Physiological / complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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