Document Detail

Stress hypertension in monkeys.
MedLine Citation:
PMID:  2150986     Owner:  NLM     Status:  MEDLINE    
1. The influence of chronic forelimb immobilization enforcing movement in upright position on blood pressure was studied in monkeys. 2. In the course of 6 months all animals subjected to immobilization became hypertensive due to a parallel increase of systolic and diastolic pressure by about 30%. The hypertension was demonstrable both in awake and anaesthetized animals and persisted even after restitution of a normal movement regime. 3. In the chronic stage (after 15 months), the plasma renin concentration was decreased by 55%, indicating that the renin-angiotensin system activation does not participate in the maintenance of the hypertensive state. The plasma volume was diminished by 18%, while the interstitial fluid volume did not differ significantly from control values. 4. It is concluded that chronic forelimb immobilization in monkeys induces a low-renin hypertension, associated with changes in extracellular fluid compartments resembling the pattern found in the hypovolaemic type of essential hypertension.
J Kunes; A N Demin; J Jelínek; K Capek; G S Belkaniya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologia Bohemoslovaca     Volume:  39     ISSN:  0369-9463     ISO Abbreviation:  Physiol Bohemoslov     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-28     Completed Date:  1991-05-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0175317     Medline TA:  Physiol Bohemoslov     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  417-23     Citation Subset:  IM; S    
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
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MeSH Terms
Blood Pressure / physiology
Blood Volume / physiology
Glomerular Filtration Rate / physiology
Hypertension / etiology,  physiopathology*
Immobilization / physiology
Macaca mulatta / physiology*
Renin / blood
Stress, Physiological / complications,  physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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