| Stress hyperglycaemia is an independent predictor of left ventricular remodelling after first anterior myocardial infarction in non-diabetic patients. | |
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MedLine Citation:
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PMID: 17314113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Stress hyperglycaemia (SH) is associated with adverse outcome in patients with acute myocardial infarction (MI) but the mechanisms underlying this association are unknown. Our hypothesis was that SH on admission for acute MI may be associated with left ventricular (LV) remodelling. METHODS AND RESULTS: We analysed LV remodelling in 162 non-diabetic patients with anterior MI. SH was defined as a glycaemia on admission >or=7 mmol/L. Systematic echocardiographic follow-up was performed at 3 months and 1 year after MI. The changes in end-diastolic volume (EDV) and end-systolic volume (ESV) from baseline to 1 year were 11.4 +/- 16.5 and 6.4 +/- 12.4 ml/m(2), respectively, in patients with SH vs. 1.9 +/- 11.1 and 0.2 +/- 8.5 ml/m(2), respectively, in patients without SH (both P < 0.0001). When LV remodelling was defined as a >20% increase in EDV, it was observed in 46% patients in the SH group vs. 19% patients in the no SH group (P = 0.0008). By multivariable analysis, baseline wall motion score index (P = 0.001) and SH (P = 0.009) were independently associated with changes in EDV. SH was an independent predictor of LV remodelling [adjusted OR: 3.22 (1.31-7.94)]. CONCLUSION: SH is a major and independent predictor of LV remodelling after anterior MI in non-diabetic patients. |
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Authors:
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Christophe Bauters; Pierre V Ennezat; Olivier Tricot; Bénédicte Lauwerier; Robert Lallemant; Hassan Saadouni; Philippe Quandalle; Olivier Jaboureck; Nicolas Lamblin; Thierry Le Tourneau; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-21 |
Journal Detail:
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Title: European heart journal Volume: 28 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-07 Completed Date: 2007-11-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 546-52 Citation Subset: IM |
Affiliation:
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Service de Cardiologie C, Hôpital Cardiologique, Centre Hospitalier Régional et Universitaire de Lille, Boul, Lille Cedex, France. cbauters@chru-lille.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Echocardiography Female Follow-Up Studies Humans Hyperglycemia / complications*, physiopathology Male Middle Aged Myocardial Infarction / physiopathology* Observer Variation Stress, Physiological / complications*, physiopathology Ventricular Remodeling / physiology* |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2007 Nov;28(22):2821; author reply 2821-2
[PMID:
17959617
]
Eur Heart J. 2007 Aug;28(16):2042; author reply 2042-3 [PMID: 17567622 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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