Document Detail

Stress hormones predict cerebrovascular re-events after transient ischemic attacks.
MedLine Citation:
PMID:  21228295     Owner:  NLM     Status:  Publisher    
BACKGROUND: TIA is a strong predictor of subsequent stroke. The hypothalamic stress hormone copeptin is an accurate prognostic marker in acute ischemic stroke. This study assessed prognostic reliability of 2 distinct stress hormones, copeptin and cortisol, for the risk stratification of re-events in patients with TIA. METHODS: We conducted a prospective study in patients admitted to the emergency department with a TIA. Clinical risk scoring using the ABCD2 score was determined and both hormones were measured in plasma on admission. The primary endpoint was a cerebrovascular re-event within 90 days. RESULTS: We included 107 consecutive patients with TIA. Re-events occurred in 10 patients (9%). Copeptin levels were higher in patients with a re-event compared with patients without re-event (p = 0.02), in contrast to cortisol (p = 0.53). Copeptin revealed a higher area under the receiver operating characteristics curve (AUC) to predict re-events compared to the ABCD2 score (AUC of 0.73 vs 0.43; p < 0.01) and improved its prognostic accuracy (AUC of combined model of 0.77; p = 0.002). CONCLUSION: Measurement of plasma copeptin but not cortisol levels in patients with TIA provides additional prognostic information beyond the ABCD2 clinical risk score alone. If confirmed in future studies, routine copeptin measurement may be an additional tool for risk stratification and targeted resource allocation after TIA.
M Katan; N Nigro; F Fluri; P Schuetz; N G Morgenthaler; F Jax; S Meckel; A Gass; R Bingisser; A Steck; L Kappos; S Engelter; B Müller; M Christ-Crain
Related Documents :
12807305 - Envenomation by the mexican beaded lizard: a case report.
17223485 - Burn patient characteristics and outcomes following resuscitation with albumin.
6589575 - Burning mouth: an analysis of 57 patients.
20407405 - Extent and magnitude of catecholamine surge in pediatric burned patients.
19506135 - A long-term prospective study of the natural course of sporadic adult-onset lower motor...
11774055 - Pearls and pitfalls in the intensive care management of guillain-barré syndrome.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-12
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Departments of Endocrinology (M.K., N.N., P.S., M.C.-C.), Neurology (M.K., F.F., A.G., A.S., L.K., S.E.), Neuroradiology (F.J., S.M., A.G.), and Internal Medicine (R.B.), University Hospital Basel, Basel, Switzerland; Research Department (N.G.M.), Brahms AG, Hennigsdorf/Berlin, Germany; and Department of Internal Medicine (B.M.), Kantonsspital Aarau, Aarau, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The impact of declining smoking on radon-related lung cancer in the United States.
Next Document:  Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease.