Document Detail

Stress hormones alter the pattern of free amino acids in human skeletal muscle.
MedLine Citation:
PMID:  8519166     Owner:  NLM     Status:  MEDLINE    
Stress hormones were infused for 6 h in healthy volunteers (n = 32). Free amino acid concentrations were determined in plasma and in skeletal muscle biopsy specimens. A triple hormone combination of adrenaline, cortisol, and glucagon raised the level of alanine in muscle, while glutamine, glutamate, the branched chain amino acids, the aromatic amino acids, and the basic amino acids decreased. Adrenaline alone partly reproduced this pattern, while a 6-h infusion of cortisol left the muscle free amino acids unaffected. In plasma all individual amino acids except alanine and glutamate decreased in the subjects receiving adrenaline or a triple-hormone combination. Altered plasma amino acid concentrations did not necessarily reflect changes in the tissue amino acid content. It is concluded that an infusion of a triple combination of stress hormones into healthy volunteers produces changes in muscle amino acid metabolism similar to those seen immediately after surgical trauma.
J Wernerman; F Hammarqvist; D Botta; E Vinars
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  13     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-26     Completed Date:  1993-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  309-19     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care, Karolinska Institute, St Göran's Hospital, Stockholm, Sweden.
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MeSH Terms
Amino Acids / blood,  metabolism*
Epinephrine / blood,  pharmacology
Glucagon / blood,  pharmacology
Hormones / pharmacology*
Hydrocortisone / blood,  pharmacology
Muscles / drug effects,  metabolism*
Stress, Psychological / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Hormones; 50-23-7/Hydrocortisone; 51-43-4/Epinephrine; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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