| Stress failure plays a major role in the development of high-altitude pulmonary oedema in rats. | |
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MedLine Citation:
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PMID: 19741034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxia and exertion are considered as the two main factors in the development of high-altitude pulmonary oedema (HAPE), however its pathophysiology remains unclear. Therefore, we established a model in which 32 Sprague-Dawley rats were randomly assigned to normoxic rest, hypoxic rest, normoxic exercise and hypoxic exercise. An altitude of 4,700 m was simulated using hypobaric hypoxia, while exercise consisted 48 h walk with 15-20 min breaks every 4 h. Arterial blood gas, bronchoalveolar lavage (BAL), lung wet-to-dry weight (W/D) ratio and histological measurements were conducted on each animal. In rats exercising in hypoxia, BAL protein and lung W/D ratio were significantly increased but no changes in BAL leukotriene B(4) and immunoglobulin M were observed. In the same group, lung histology showed typical haemorrhagic lung oedema and disruption of both alveolar epithelium and capillary endothelium while hypoxia or exertion alone only induced slight endothelium and epithelium swelling/disruption. Our study established a direct link between histological and physiological evidence of HAPE-like symptoms and we demonstrated that hypoxia and exertion can synergistically induce HAPE-like symptoms in Sprague-Dawley rats without inducing lung inflammation. We therefore propose that alveolar epithelium and capillary endothelium stress failure play a major role in the development of HAPE. |
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Authors:
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C Bai; J She; A Goolaerts; Y Song; C Shen; J Shen; Q Hong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-09 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 35 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 584-91 Citation Subset: IM |
Affiliation:
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Dept of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China. bai.chunxue@zs-hospital.sh.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Altitude Sickness
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pathology,
physiopathology* Animals Anoxia / physiopathology Blood Gas Analysis Blood-Air Barrier / injuries, pathology, physiopathology* Bronchoalveolar Lavage Fluid Disease Models, Animal Endothelium, Vascular / injuries*, pathology, physiopathology* Male Microscopy, Electron Physical Exertion / physiology Pulmonary Edema / pathology, physiopathology* Rats Rats, Sprague-Dawley |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2010 Mar;35(3):470-2
[PMID:
20190325
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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