Document Detail

Stress failure plays a major role in the development of high-altitude pulmonary oedema in rats.
MedLine Citation:
PMID:  19741034     Owner:  NLM     Status:  MEDLINE    
Hypoxia and exertion are considered as the two main factors in the development of high-altitude pulmonary oedema (HAPE), however its pathophysiology remains unclear. Therefore, we established a model in which 32 Sprague-Dawley rats were randomly assigned to normoxic rest, hypoxic rest, normoxic exercise and hypoxic exercise. An altitude of 4,700 m was simulated using hypobaric hypoxia, while exercise consisted 48 h walk with 15-20 min breaks every 4 h. Arterial blood gas, bronchoalveolar lavage (BAL), lung wet-to-dry weight (W/D) ratio and histological measurements were conducted on each animal. In rats exercising in hypoxia, BAL protein and lung W/D ratio were significantly increased but no changes in BAL leukotriene B(4) and immunoglobulin M were observed. In the same group, lung histology showed typical haemorrhagic lung oedema and disruption of both alveolar epithelium and capillary endothelium while hypoxia or exertion alone only induced slight endothelium and epithelium swelling/disruption. Our study established a direct link between histological and physiological evidence of HAPE-like symptoms and we demonstrated that hypoxia and exertion can synergistically induce HAPE-like symptoms in Sprague-Dawley rats without inducing lung inflammation. We therefore propose that alveolar epithelium and capillary endothelium stress failure play a major role in the development of HAPE.
C Bai; J She; A Goolaerts; Y Song; C Shen; J Shen; Q Hong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-09
Journal Detail:
Title:  The European respiratory journal     Volume:  35     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-06-24     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  584-91     Citation Subset:  IM    
Dept of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Altitude Sickness / pathology,  physiopathology*
Anoxia / physiopathology
Blood Gas Analysis
Blood-Air Barrier / injuries,  pathology,  physiopathology*
Bronchoalveolar Lavage Fluid
Disease Models, Animal
Endothelium, Vascular / injuries*,  pathology,  physiopathology*
Microscopy, Electron
Physical Exertion / physiology
Pulmonary Edema / pathology,  physiopathology*
Rats, Sprague-Dawley
Comment In:
Eur Respir J. 2010 Mar;35(3):470-2   [PMID:  20190325 ]

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