| Stress erythropoiesis: new signals and new stress progenitor cells. | |
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MedLine Citation:
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PMID: 21372709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Acute anemic stress induces a physiological response that includes the rapid development of new erythrocytes. This process is referred to as stress erythropoiesis, which is distinct from steady state erythropoiesis. Much of what we know about stress erythropoiesis comes from the analysis of murine models. In this review, we will discuss our current understanding of the mechanisms that regulate stress erythropoiesis in mice and discuss outstanding questions in the field. RECENT FINDINGS: Stress erythropoiesis occurs in the murine spleen, fetal liver and adult liver. The signals that regulate this process are Hedgehog, bone morphogenetic protein 4 (BMP4), stem cell factor and hypoxia. Recent findings show that stress erythropoiesis utilizes a population of erythroid-restricted self-renewing stress progenitors. Although the BMP4-dependent stress erythropoiesis pathway was first characterized during the recovery from acute anemia, analysis of a mouse model of chronic anemia demonstrated that activation of the BMP4-dependent stress erythropoiesis pathway provides compensatory erythropoiesis in response to chronic anemia as well. SUMMARY: The BMP4-dependent stress erythropoiesis pathway plays a key role in the recovery from acute anemia and new data show that this pathway compensates for ineffective steady state erythropoiesis in a murine model of chronic anemia. The identification of a self-renewing population of stress erythroid progenitors in mice suggests that therapeutic manipulation of this pathway may be useful for the treatment of human anemia. However, the development of new therapies will await the characterization of an analogous pathway in humans. |
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Authors:
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Robert F Paulson; Lei Shi; Dai-Chen Wu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in hematology Volume: 18 ISSN: 1531-7048 ISO Abbreviation: Curr. Opin. Hematol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-14 Completed Date: 2011-10-17 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 9430802 Medline TA: Curr Opin Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 139-45 Citation Subset: IM |
Affiliation:
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Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pennsylvania, USA. rfp5@psu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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blood* Animals Erythropoiesis* Humans Signal Transduction* Stem Cells / metabolism* Stress, Physiological* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK080040/DK/NIDDK NIH HHS; R01 DK080040-02/DK/NIDDK NIH HHS; R01 DK080040-03/DK/NIDDK NIH HHS; R01DK080040-01/DK/NIDDK NIH HHS |
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