Document Detail

Stress echo results predict mortality: a large-scale multicenter prospective international study.
MedLine Citation:
PMID:  12598070     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The purpose of this study was to assess the long-term value of pharmacologic stress echocardiography with either dipyridamole or dobutamine (DET) for prediction of cardiac death in patients with proven or suspected coronary artery disease (CAD). BACKGROUND: Stress echocardiography is an established, cost-effective technique for the detection of CAD. METHODS: From the Echo Persantine International Cooperative-Echo Dobutamine International Cooperative data bank, 7,333 patients (5,452 males; 59 +/- 10 years) underwent pharmacologic stress echocardiography with either high-dose dipyridamole (0.84 mg/kg over 10 min) (n = 4,984) or high-dose dobutamine (up to 40 microg/kg/3 min) (n = 2,349) for diagnostic purposes. Patients were followed up for a mean of 2.6 years (range 1 to 206 months). RESULTS: The DET was positive for myocardial ischemia in 2,854 (35%) patients and negative in 4,479 (61%) patients. During the follow-up there were 161 cardiac deaths (sudden death and fatal myocardial infarction) (2.1% of the total population). Kaplan-Meier survival estimates showed a significantly better outcome for those patients with a negative pharmacologic stress echocardiography test compared with those with a positive test (92 vs. 71.2%, p = 0.0000). CONCLUSIONS: Pharmacologic stress echocardiography with either dipyridamole or dobutamine is effective in predicting cardiac death during a long-term follow-up. A negative stress echocardiography test result is related to a favorable outcome.
Rosa Sicari; Emilio Pasanisi; Lucia Venneri; Patrizia Landi; Lauro Cortigiani; Eugenio Picano; ;
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  41     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-03-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-95     Citation Subset:  AIM; IM    
National Council of Research, Institute of Clinical Physiology, Via G. Moruzzi 1, 56125 Pisa, Italy.
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MeSH Terms
Cardiotonic Agents / diagnostic use
Coronary Artery Disease / mortality*,  ultrasonography*
Dipyridamole / diagnostic use
Dobutamine / diagnostic use
Echocardiography, Stress*
Follow-Up Studies
International Cooperation*
Middle Aged
Platelet Aggregation Inhibitors / diagnostic use
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Time Factors
Reg. No./Substance:
0/Cardiotonic Agents; 0/Platelet Aggregation Inhibitors; 34368-04-2/Dobutamine; 58-32-2/Dipyridamole

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