| Stress echo results predict mortality: a large-scale multicenter prospective international study. | |
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MedLine Citation:
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PMID: 12598070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The purpose of this study was to assess the long-term value of pharmacologic stress echocardiography with either dipyridamole or dobutamine (DET) for prediction of cardiac death in patients with proven or suspected coronary artery disease (CAD). BACKGROUND: Stress echocardiography is an established, cost-effective technique for the detection of CAD. METHODS: From the Echo Persantine International Cooperative-Echo Dobutamine International Cooperative data bank, 7,333 patients (5,452 males; 59 +/- 10 years) underwent pharmacologic stress echocardiography with either high-dose dipyridamole (0.84 mg/kg over 10 min) (n = 4,984) or high-dose dobutamine (up to 40 microg/kg/3 min) (n = 2,349) for diagnostic purposes. Patients were followed up for a mean of 2.6 years (range 1 to 206 months). RESULTS: The DET was positive for myocardial ischemia in 2,854 (35%) patients and negative in 4,479 (61%) patients. During the follow-up there were 161 cardiac deaths (sudden death and fatal myocardial infarction) (2.1% of the total population). Kaplan-Meier survival estimates showed a significantly better outcome for those patients with a negative pharmacologic stress echocardiography test compared with those with a positive test (92 vs. 71.2%, p = 0.0000). CONCLUSIONS: Pharmacologic stress echocardiography with either dipyridamole or dobutamine is effective in predicting cardiac death during a long-term follow-up. A negative stress echocardiography test result is related to a favorable outcome. |
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Authors:
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Rosa Sicari; Emilio Pasanisi; Lucia Venneri; Patrizia Landi; Lauro Cortigiani; Eugenio Picano; ; |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 41 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-24 Completed Date: 2003-03-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 589-95 Citation Subset: AIM; IM |
Affiliation:
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National Council of Research, Institute of Clinical Physiology, Via G. Moruzzi 1, 56125 Pisa, Italy. rosas@ifc.cnr.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiotonic Agents / diagnostic use Coronary Artery Disease / mortality*, ultrasonography* Dipyridamole / diagnostic use Dobutamine / diagnostic use Echocardiography, Stress* Female Follow-Up Studies Humans International Cooperation* Male Middle Aged Platelet Aggregation Inhibitors / diagnostic use Predictive Value of Tests Prospective Studies Reproducibility of Results Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 0/Platelet Aggregation Inhibitors; 34368-04-2/Dobutamine; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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