Document Detail

Stress control and human nutrition.
MedLine Citation:
PMID:  15460899     Owner:  NLM     Status:  MEDLINE    
Stress is a pervasive factor in everyday life that critically affects development and functioning. Severe and prolonged stress exposure impairs homeostatic mechanisms, particularly associated with the onset of depressive illness. Brain food is aimed at preventing as well as treating a growing number of stress-related mental disorders. Some topics on the association of stress and nutrition is reviewed. (1) An increased activity of serotonergic neurons in the brain is an established consequence of stress. An increase in brain tryptophan levels on the order of that produced by eating a carbohydrate-rich/protein-poor meal causes parallel increases in the amounts of serotonin released into synapses. (2) Eating is thought to be suppressed during stress, due to anorectic effects of corticotrophin releasing hormone, and increased during recovery from stress, due to appetite stimulating effects of residual cortisol. (3) A strong inverse association between coffee intake and risk of suicide. (4) Night eating syndrome has been found to occur during periods of stress and is associated with poor results at attempts to lose weight and disturbances in the hypothalamic-pituitary-adrenal axis. (5) Dietary antioxidants present in fruits and vegetables may improve cognitive function. Therefore, it is concluded that the establishment of functional foods that correctly regulate stress response must be firmly based upon scientific knowledge and legal regulation.
Eiji Takeda; Junji Terao; Yutaka Nakaya; Ken-ichi Miyamoto; Yoshinobu Baba; Hiroshi Chuman; Ryuji Kaji; Tetsuro Ohmori; Kazuhito Rokutan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The journal of medical investigation : JMI     Volume:  51     ISSN:  1343-1420     ISO Abbreviation:  J. Med. Invest.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-10-05     Completed Date:  2004-11-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9716841     Medline TA:  J Med Invest     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  139-45     Citation Subset:  IM    
Department of Clinical Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
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MeSH Terms
Antioxidants / metabolism
Brain / physiopathology
Dietary Carbohydrates / administration & dosage
Feeding Behavior
Hydrocortisone / physiology
Nutritional Physiological Phenomena*
Serotonin / metabolism,  physiology
Stress, Physiological / diet therapy,  physiopathology,  prevention & control*
Suicide / prevention & control
Reg. No./Substance:
0/Antioxidants; 0/Coffee; 0/Dietary Carbohydrates; 50-23-7/Hydrocortisone; 50-67-9/Serotonin

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