Document Detail

Stress and cardiovascular disease.
MedLine Citation:
PMID:  22473079     Owner:  NLM     Status:  MEDLINE    
The physiological reaction to psychological stress, involving the hypothalamic-pituitary-adrenocortical and sympatho-adrenomedullary axes, is well characterized, but its link to cardiovascular disease risk is not well understood. Epidemiological data show that chronic stress predicts the occurrence of coronary heart disease (CHD). Employees who experience work-related stress and individuals who are socially isolated or lonely have an increased risk of a first CHD event. In addition, short-term emotional stress can act as a trigger of cardiac events among individuals with advanced atherosclerosis. A stress-specific coronary syndrome, known as transient left ventricular apical ballooning cardiomyopathy or stress (Takotsubo) cardiomyopathy, also exists. Among patients with CHD, acute psychological stress has been shown to induce transient myocardial ischemia and long-term stress can increase the risk of recurrent CHD events and mortality. Applications of the 'stress concept' (the understanding of stress as a risk factor and the use of stress management) in the clinical settings have been relatively limited, although the importance of stress management is highlighted in European guidelines for cardiovascular disease prevention.
Andrew Steptoe; Mika Kivimäki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-03
Journal Detail:
Title:  Nature reviews. Cardiology     Volume:  9     ISSN:  1759-5010     ISO Abbreviation:  Nat Rev Cardiol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-24     Completed Date:  2012-09-24     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101500075     Medline TA:  Nat Rev Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  360-70     Citation Subset:  IM    
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MeSH Terms
Cardiovascular Diseases / epidemiology*,  mortality,  prevention & control,  psychology
Chronic Disease
Mental Health*
Practice Guidelines as Topic
Risk Assessment
Risk Factors
Stress, Psychological / epidemiology*,  mortality,  prevention & control
Grant Support
G0902037//Medical Research Council; G19/35//Medical Research Council; G8802774//Medical Research Council; RG/07/008/23674//British Heart Foundation; RG/10/005/28296//British Heart Foundation; //Medical Research Council
Comment In:
Nat Rev Cardiol. 2012 Oct;9(10):598; author reply 598   [PMID:  22889951 ]

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