| Stress cardiac single-photon emission computed tomographic imaging late after coronary artery bypass surgery for risk stratification and estimation of time to cardiac events. | |
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MedLine Citation:
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PMID: 18603052 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We assessed predictors and temporal characteristics of cardiac risk in patients undergoing stress single-photon emission computed tomography after coronary artery bypass grafting. METHODS: Stress cardiac tomography was performed in 362 patients 5 years after coronary artery bypass grafting. Cardiac death and myocardial infarction were considered as events. Cox proportional hazards analysis was used to identify predictors of events and parametric survival analysis to predict time to events. RESULTS: During a median follow-up of 27 months, 22 cardiac events occurred (6.1% cumulative event rate). At multivariable Cox analysis, ischemia at cardiac tomography (hazards ratio 3.7, 95% confidence interval 1.5-9.1; P = .004), and diabetes (hazards ratio 3.6, 95% confidence interval 1.5-8.5; P = .006) resulted in independent predictors of events. Event-free survival was 96% in patients with normal cardiac tomography, 86% in those with abnormal tomography without ischemia, and 70% in those with (log-rank 10.6, P for trend = .008). The parametric survival model revealed that the cardiac risk was greater for all time intervals and accelerated more over time in patients with ischemia than in those without (chi(2) 21.4, P < .0001). Patients without diabetes and normal cardiac tomography remained below a defined risk level (5%) for the entire follow-up period. CONCLUSION: Stress cardiac tomography performed 5 years after coronary artery bypass grafting is useful to characterize the risk of cardiac events and its temporal variation. Parametric survival model estimates the predicted time to risk and the level of risk at specific time intervals after coronary artery bypass grafting. |
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Authors:
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Wanda Acampa; Mario Petretta; Laura Evangelista; Gianantonio Nappi; Luca Luongo; Maria Piera Petretta; Alberto Cuocolo |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2008-05-07 |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 136 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-08 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 46-51 Citation Subset: AIM; IM |
Affiliation:
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Institute of Biostructures and Bioimages, National Council of Research, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Causality Comorbidity Coronary Artery Bypass* Coronary Artery Disease / epidemiology, surgery Death, Sudden, Cardiac / epidemiology, prevention & control Diabetes Mellitus / epidemiology Disease-Free Survival Exercise Test* Female Follow-Up Studies Humans Male Middle Aged Myocardial Infarction / epidemiology, prevention & control, radionuclide imaging*, surgery* Myocardial Ischemia / epidemiology, radionuclide imaging* Postoperative Care / methods* Prevalence Recurrence / prevention & control Risk Assessment Sex Distribution Tomography, Emission-Computed, Single-Photon* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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