Document Detail

Stress and beta-adrenergic receptor binding in the rat's brain.
MedLine Citation:
PMID:  6269706     Owner:  NLM     Status:  MEDLINE    
The effect of acute and chronic electric shocks on beta-adrenergic receptor binding in the rat's brain was investigated. Beta-adrenergic receptor subsensitivity in the cortex was induced by chronic shocks, but not by acute shocks. This reduction appears to be due to a decreased number of receptors. It seems that stress, by increasing intrasynaptic norepinephrine levels resulting from an accelerated turnover rate, causes beta-adrenergic receptor subsensitivity.
S Nomura; M Watanabe; N Ukei; T Nakazawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  224     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Dihydroalprenolol / metabolism
Rats, Inbred Strains
Receptors, Adrenergic / metabolism*
Receptors, Adrenergic, alpha / metabolism*
Stress, Physiological / metabolism*
Reg. No./Substance:
0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 60106-89-0/Dihydroalprenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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