| Stress-Induced Hyperglycemia in Healthy Bungee Jumpers Without Diabetes Due to Decreased Pancreatic β-Cell Function and Increased Insulin Resistance. | |
| | |
MedLine Citation:
|
PMID: 22283617 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Background: Acute diseases are associated with increased stress and immune responses. Both of these responses are associated with disturbances of glucose metabolism, and it is therefore difficult to ascertain whether these disturbances are related to increased stress alone or a result of the systemic inflammatory response. We investigated the effects that acute stress has on glucose metabolism in an acute stress model that is not accompanied by an increased immune response. Subjects and Methods: Glucose levels as well as pancreatic β-cell function, insulin resistance, and parameters of stress and immune responses were assessed in healthy bungee jumpers 2 h before, immediately before, and after the jump. Results: Glucose levels and stress hormones were increased, right before and after the jump, whereas the immune response was decreased. Pancreatic β-cell function was decreased right before the jump, and insulin resistance was increased right after the jump. Higher levels of cortisol correlated with increased insulin resistance after the jump. Furthermore, larger increments of cortisol before and of epinephrine after the jump were associated with decreased pancreatic β-cell function. Conclusions: Acute stress in healthy bungee jumpers induces acute disturbances of glucose metabolism that are independent from a systemic inflammatory response. |
| | |
Authors:
|
Nyika D Kruyt; David J van Westerloo; J Hans Devries |
Related Documents
:
|
18604647 - Early diagnosis and prevention of diabetes in developing countries. 19837917 - Wolcott-rallison syndrome is the most common genetic cause of permanent neonatal diabet... 11679457 - Changes in bmi and weight before and after the development of type 2 diabetes. 16983797 - Common reasons for hospitalization among adult patients with diabetes. 16435997 - The metabolic syndrome is associated with increased risk of colorectal adenoma developm... 15209357 - Prospective study of post-partum thyroid immune dysfunctions in type 1 diabetic women a... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
|
Title: Diabetes technology & therapeutics Volume: - ISSN: 1557-8593 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Department of Neurology, Slotervaartziekenhuis Amsterdam , Amsterdam, The Netherlands . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Molecular Characterization of Salmonella enterica Serotype Enteritidis Isolates from Humans by Antim...
Next Document: Multigram Synthesis of Isobutyl-?-C-galactoside as a Substitute of Isopropylthiogalactoside for Exog...