Document Detail


Stress Doppler echocardiography using dobutamine in coronary patients with and without ischaemia induction.
MedLine Citation:
PMID:  1505549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the effects of dobutamine on pulsed-Doppler left ventricular ejection dynamics and its utility for evaluation of coronary disease (CAD) we studied 10 patients with normal coronaries (Group 1) and 24 patients with significant CAD (greater than or equal to 70% diameter stenosis) using a graded stress infusion (5 to 20 micrograms.kg-1.min-1). Two-dimensional echocardiography was performed to detect regional asynergy and analysed using an 11-segment model. Patients with CAD were divided into those with (Group 3, n = 14) and without (Group 2, n = 10) inducible ischaemia; six patients had reversible involvement of greater than or equal to three segments (subset 3A). Groups were well matched for baseline left ventricular function and all studies were carried out while the patients were not taking cardioactive therapy. Hyperkinetic wall motion was typical and exaggerated hyperkinesis of normal segments was commonly seen in those with baseline (n = 9) or reversible asynergy (n = 14). Normals and CAD patients showed comparable changes in heart rate and blood pressure (P = NS between groups).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
P K Mazeika; A Nadazdin; C M Oakley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  13     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-23     Completed Date:  1992-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1020-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Hammersmith Hospital and RPMS, London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cardiac Output / drug effects,  physiology
Cardiac Volume / drug effects,  physiology
Coronary Angiography
Coronary Disease / physiopathology,  ultrasonography*
Dobutamine / diagnostic use*
Echocardiography, Doppler* / drug effects
Exercise Test* / drug effects
Female
Heart Catheterization
Hemodynamics / drug effects,  physiology*
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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