Document Detail


Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia.
MedLine Citation:
PMID:  19307479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: This large, prospective, multicentric study was performed to analyze the distribution of tricuspid regurgitation velocity (TRV) values during exercise and hypoxia in relatives of patients with idiopathic and familial pulmonary arterial hypertension (PAH) and in healthy control subjects. We tested the hypothesis that relatives of idiopathic/familial PAH patients display an enhanced frequency of hypertensive TRV response to stress and that this response is associated with mutations in the bone morphogenetic protein receptor II (BMPR2) gene.
METHODS AND RESULTS: TRV was estimated by Doppler echocardiography during supine bicycle exercise in normoxia and during 120 minutes of normobaric hypoxia (FIO(2)=12%; approximately 4500 m) in 291 relatives of 109 PAH patients and in 191 age-matched control subjects. Mean maximal TRVs were significantly higher in PAH relatives during both exercise and hypoxia. During exercise, 10% of control subjects but 31.6% of relatives (P<0.0001) exceeded the 90% quantile of mean maximal TRV seen in control subjects. Hypoxia revealed hypertensive TRV in 26% of relatives (P=0.0029). Among control subjects, TRV at rest was not related to age, sex, body mass index, systemic blood pressure, smoking status, or heart rate. Within kindreds identified as harboring deleterious mutations of the BMPR2 gene, a hypertensive TRV response occurred significantly more often compared with those without detected mutations.
CONCLUSIONS: Pulmonary hypertensive response to exercise and hypoxia in idiopathic/familial PAH relatives appears as a genetic trait with familial clustering, being correlated to but not caused by a BMPR2 mutation. The suitability of this trait to predict manifest PAH development should be addressed in long-term follow-up studies.
Authors:
Ekkehard Grünig; Sylvia Weissmann; Nicola Ehlken; Anna Fijalkowska; Christine Fischer; Thierry Fourme; Nazzareno Galié; Ardeschir Ghofrani; Rachel E Harrison; Sandrine Huez; Marc Humbert; Bart Janssen; Jaroslaw Kober; Rolf Koehler; Rajiv D Machado; Derliz Mereles; Robert Naeije; Horst Olschewski; Steeve Provencher; Frank Reichenberger; Kathleen Retailleau; Guido Rocchi; Gérald Simonneau; Adam Torbicki; Richard Trembath; Werner Seeger
Related Documents :
6402469 - Effects of hypercapnia, hypoxia, and rebreathing on heart rate response during apnea.
12385729 - Exercise-dependent ventilatory sensitivity to hypoxia in andean natives.
17323069 - The effect of acute hypoxia on left ventricular function during exercise.
2913959 - Surgical correction of venous incompetence restores normal skin blood flow and abolishe...
3688259 - Adenosine and hypoxia effects on atrioventricular node of adult and neonatal rabbit hea...
698869 - Hypoxic ventilatory responses during thiopentone sedation and anaesthesia in man.
17884649 - Physiological disturbance and recovery dynamics of bonefish (albula vulpes), a tropical...
16312139 - Febuxostat (teijin/ipsen/tap).
12840629 - Effects of spinal cord lesion level upon thermoregulation during exercise in the heat.
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-03-23
Journal Detail:
Title:  Circulation     Volume:  119     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-07     Completed Date:  2009-04-30     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1747-57     Citation Subset:  AIM; IM    
Affiliation:
Department of Pneumology Thoraxclinic, University Hospital Heidelberg, Amalienstrasse 5, D-69126 Heidelberg, Germany. ekkehard.gruenig@thoraxklinik-heidelberg.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / genetics,  physiopathology
Blood Pressure / physiology
Bone Morphogenetic Protein Receptors, Type II / genetics*
Echocardiography, Doppler*
Europe
Exercise / physiology
Exercise Test
Family
Female
Heart Rate / physiology
Humans
Hypertension / genetics,  physiopathology
Hypertension, Pulmonary / genetics*,  physiopathology,  ultrasonography*
Male
Middle Aged
Prospective Studies
Rest / physiology
Tricuspid Valve Insufficiency / genetics*,  physiopathology,  ultrasonography*
Young Adult
Chemical
Reg. No./Substance:
EC 2.7.11.30/BMPR2 protein, human; EC 2.7.11.30/Bone Morphogenetic Protein Receptors, Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage.
Next Document:  Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial ...