| Stress Doppler echocardiography for identification of susceptibility to high altitude pulmonary edema. | |
| | |
MedLine Citation:
|
PMID: 10732898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This prospective single-blinded study was performed to quantitate noninvasive pulmonary artery systolic pressure (PASP) responses to prolonged acute hypoxia and normoxic exercise. BACKGROUND: Hypoxia-induced excessive rise in pulmonary artery pressure is a key factor in high-altitude pulmonary edema (HAPE). We hypothesized that subjects susceptible to HAPE (HAPE-S) have increased pulmonary artery pressure response not only to hypoxia but also to exercise. METHODS: PASP was estimated at 45, 90 and 240 min of hypoxia (FiO2 = 12%) and during supine bicycle exercise in normoxia using Doppler-echocardiography in nine HAPE-S and in 11 control subjects. RESULTS: In the control group, mean PASP increased from 26+/-2 to 37+/-4 mm Hg (deltaPASP 10.3+/-2 mm Hg) after 90 min of hypoxia and from 27+/-4 to 36+/-3 mm Hg (deltaPASP 8+/-2 mm Hg) during exercise. In contrast, all HAPE-S subjects revealed significantly greater increases (p = 0.002 vs. controls) in mean PASP both during hypoxia (from 28+/-4 to 57+/-10 mm Hg, deltaPASP 28.7+/-6 mm Hg) and during exercise (from 28+/-4 to 55+/-11 mm Hg, deltaPASP 27+/-8 mm Hg) than did control subjects. Stress echocardiography allowed discrimination between groups without overlap using a cut off PASP value of 45 mm Hg at work rates less than 150 W. CONCLUSIONS: These data indicate that HAPE-S subjects may have abnormal pulmonary vascular responses not only to hypoxia but also to supine bicycle exercise under normoxic conditions. Thus, Doppler echocardiography during supine bicycle exercise or after 90 min of hypoxia may be useful noninvasive screening methods to identify subjects susceptible to HAPE. |
| | |
Authors:
|
E Grünig; D Mereles; W Hildebrandt; E R Swenson; W Kübler; H Kuecherer; P Bärtsch |
Related Documents
:
|
3135188 - Effects of acute hypoxia and co2 inhalation on systemic and peripheral oxygen uptake an... 6859278 - Effect of hypoxia on ouabain inhibition of sodium pump in newborn rabbit myocardium. 7661348 - Influences of subanesthetic isoflurane on ventilatory control in humans. 22419238 - Rehabilitation strategy in the elderly. 3135188 - Effects of acute hypoxia and co2 inhalation on systemic and peripheral oxygen uptake an... 7636388 - The effect of cell-free hemoglobin on intravascular clearance and cellular, plasma, and... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 35 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2000 Mar |
Date Detail:
|
Created Date: 2000-03-31 Completed Date: 2000-03-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 980-7 Citation Subset: AIM; IM; S |
Affiliation:
|
Department of Cardiology, University of Heidelberg, Germany. ekkehard_gruenig@med.uni-heidelberg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Altitude Sickness / physiopathology, ultrasonography* Anoxia / physiopathology, ultrasonography Blood Gas Analysis Echocardiography, Doppler* Exercise Test* Humans Male Middle Aged Mountaineering Prospective Studies Pulmonary Edema / physiopathology, ultrasonography* Pulmonary Wedge Pressure / physiology Risk Factors Single-Blind Method Systole / physiology Ventricular Function, Left / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Utilization of coronary angiography and revascularization after acute myocardial infarction in men a...
Next Document: Balloon angioplasty of native coarctation: clinical outcomes and predictors of success.