Document Detail


Stress alters rates and types of loss of heterozygosity in Candida albicans.
MedLine Citation:
PMID:  21791579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPORTANCE: Stress-induced mutagenesis fuels the evolution of bacterial pathogens and is mainly driven by genetic changes via mitotic recombination. Little is known about this process in other organisms. Candida albicans, an opportunistic fungal pathogen, causes infections that require adaptation to different host environmental niches. We measured the rates of LOH and the types of LOH events that appeared in the absence and in the presence of physiologically relevant stresses and found that stress causes a significant increase in the rates of LOH and that this increase is proportional to the degree of stress. Furthermore, the types of LOH events that arose differed in a stress-dependent manner, indicating that eukaryotic cells generate increased genetic diversity in response to a range of stress conditions. We propose that this "stress-induced LOH" facilitates the rapid adaptation of C. albicans, which does not undergo meiosis, to changing environments within the host.
Authors:
A Forche; D Abbey; T Pisithkul; M A Weinzierl; T Ringstrom; D Bruck; K Petersen; J Berman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-26
Journal Detail:
Title:  mBio     Volume:  2     ISSN:  2150-7511     ISO Abbreviation:  MBio     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-11-15     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101519231     Medline TA:  MBio     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Affiliation:
Department of Biology, Bowdoin College, Brunswick, Maine, USA.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / toxicity
Candida albicans / drug effects,  genetics,  physiology*,  radiation effects
Hot Temperature
Loss of Heterozygosity*
Mitosis
Oxidative Stress
Recombination, Genetic
Stress, Physiological*
Grant Support
ID/Acronym/Agency:
P20RR016463/RR/NCRR NIH HHS; R01 AI062427-08/AI/NIAID NIH HHS; R01AI0624273/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents
Comments/Corrections
Comment In:
MBio. 2011;2(5). pii: e00200-11. doi: 10.1128/mBio.00200-11   [PMID:  21933916 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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