Document Detail


Streptokinase-producing streptococci grown in human plasma acquire unregulated cell-associated plasmin activity.
MedLine Citation:
PMID:  1386099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Group A streptococci grown in the presence of human plasma generated plasmin from plasminogen and captured the functional enzyme to a specific cell-surface receptor. Bacteria-bound plasmin was not regulated by alpha 2-antiplasmin present in the medium. The ability of the bacteria to acquire cell-associated plasmin activity was dependent on both the presence of plasminogen in the culture medium and the production of a bacterial plasminogen activator, streptokinase. The ability of group A streptococci to produce a plasminogen activator and capture resulting plasmin in an unregulatable form could provide the organism with a mechanism for invasion of normal tissue barriers.
Authors:
R Lottenberg; L E DesJardin; H Wang; M D Boyle
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  166     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-25     Completed Date:  1992-08-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  436-40     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University of Florida College of Medicine, Gainesville 32610-0277.
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MeSH Terms
Descriptor/Qualifier:
Blotting, Western
Culture Media
Electrophoresis, Polyacrylamide Gel
Fibrinolysin / biosynthesis*,  metabolism
Humans
Plasma / metabolism*
Plasminogen / metabolism*
Streptococcus pyogenes / enzymology,  metabolism*
Streptokinase / biosynthesis*
Grant Support
ID/Acronym/Agency:
HL-41898/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Culture Media; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase; EC 3.4.21.7/Fibrinolysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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