| Streptokinase morbidity--more common than previously recognised. | |
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MedLine Citation:
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PMID: 1388352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Streptokinase is the thrombolytic agent most commonly used for the treatment of acute myocardial infarction. We report eight patients who developed late uncommon adverse reactions to streptokinase probably due to immune complex disease. The clinical manifestations included vasculitic rashes, abnormal renal and liver function tests and a syndrome resembling adult respiratory distress syndrome. Major adverse events with streptokinase such as stroke, bleeding and other allergic reactions, have been previously documented but the morbidity related to delayed reactions has not been widely recognised. These reactions produced significant morbidity resulting in prolonged hospital stay and may need to be considered in the decision to use streptokinase. |
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Authors:
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W J Siebert; R W Ayres; M T Bulling; C M Thomas; R B Minson; P E Aylward |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Australian and New Zealand journal of medicine Volume: 22 ISSN: 0004-8291 ISO Abbreviation: Aust N Z J Med Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-10-19 Completed Date: 1992-10-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1264322 Medline TA: Aust N Z J Med Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 129-33 Citation Subset: IM |
Affiliation:
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Department of Pharmacy, Flinders Medical Centre, Adelaide, SA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Drug Hypersensitivity / etiology* Humans Hypersensitivity, Delayed / chemically induced, immunology Immune Complex Diseases / immunology Male Middle Aged Myocardial Infarction / drug therapy Streptokinase / adverse effects*, immunology |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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