Document Detail

Streptokinase morbidity--more common than previously recognised.
MedLine Citation:
PMID:  1388352     Owner:  NLM     Status:  MEDLINE    
Streptokinase is the thrombolytic agent most commonly used for the treatment of acute myocardial infarction. We report eight patients who developed late uncommon adverse reactions to streptokinase probably due to immune complex disease. The clinical manifestations included vasculitic rashes, abnormal renal and liver function tests and a syndrome resembling adult respiratory distress syndrome. Major adverse events with streptokinase such as stroke, bleeding and other allergic reactions, have been previously documented but the morbidity related to delayed reactions has not been widely recognised. These reactions produced significant morbidity resulting in prolonged hospital stay and may need to be considered in the decision to use streptokinase.
W J Siebert; R W Ayres; M T Bulling; C M Thomas; R B Minson; P E Aylward
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Australian and New Zealand journal of medicine     Volume:  22     ISSN:  0004-8291     ISO Abbreviation:  Aust N Z J Med     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-10-19     Completed Date:  1992-10-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1264322     Medline TA:  Aust N Z J Med     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  129-33     Citation Subset:  IM    
Department of Pharmacy, Flinders Medical Centre, Adelaide, SA.
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MeSH Terms
Drug Hypersensitivity / etiology*
Hypersensitivity, Delayed / chemically induced,  immunology
Immune Complex Diseases / immunology
Middle Aged
Myocardial Infarction / drug therapy
Streptokinase / adverse effects*,  immunology
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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