Document Detail

Streptokinase, complement activation and hypotension.
MedLine Citation:
PMID:  9298105     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to establish whether complement activation is the cause of transient hypotension during streptokinase infusion in patients with acute myocardial infarction. Thirteen patients with suspected acute myocardial infarction and treated with streptokinase were included. Complement 3d (C3d) as an indicator of complement activation was assessed in venous blood and blood pressure was measured. Ten patients had verified myocardial infarction. Three patients did not. Five patients developed an increase in C3d blood levels of more than 200% within 30 min. All patients developed a transient fall in blood pressure during infusion of streptokinase. This was related neither to presence of myocardial infarction nor to degree of complement activation. The mechanism of hypotension observed following the administration of streptokinase is not through complement activation, and thus how streptokinase induces hypotension is still obscure.
A Pachaï; A K Erlendsson; I Brandslund
Related Documents :
1551265 - Electrophysiologic and antiarrhythmic effects of magnesium in patients with inducible v...
17670355 - Does magnesium prophylaxis reduce the incidence of atrial fibrillation following corona...
11137825 - Magnesium use in the treatment of acute myocardial infarction in the united states (obs...
2985675 - Effect of coronary artery recanalization on right ventricular function in patients with...
12975595 - The effect of quinapril on functional status of elderly patients with diastolic heart f...
22530875 - Current and emerging indications for implantable cardiac monitors.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  105     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-03     Completed Date:  1997-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  IM    
Department of Medicine, Vejle County Hospital, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Complement Activation*
Complement C3d / analysis
Hypotension / etiology*
Infusions, Intravenous
Middle Aged
Myocardial Infarction / therapy*
Streptokinase / adverse effects*
Reg. No./Substance:
80295-45-0/Complement C3d; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prevention of onset in an insulin-dependent diabetes mellitus model, NOD mice, by oral feeding of La...
Next Document:  Elevated frequency of p53-independent apoptosis after irradiation increases levels of DNA breaks in ...