Document Detail


Streptokinase, complement activation and hypotension.
MedLine Citation:
PMID:  9298105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to establish whether complement activation is the cause of transient hypotension during streptokinase infusion in patients with acute myocardial infarction. Thirteen patients with suspected acute myocardial infarction and treated with streptokinase were included. Complement 3d (C3d) as an indicator of complement activation was assessed in venous blood and blood pressure was measured. Ten patients had verified myocardial infarction. Three patients did not. Five patients developed an increase in C3d blood levels of more than 200% within 30 min. All patients developed a transient fall in blood pressure during infusion of streptokinase. This was related neither to presence of myocardial infarction nor to degree of complement activation. The mechanism of hypotension observed following the administration of streptokinase is not through complement activation, and thus how streptokinase induces hypotension is still obscure.
Authors:
A Pachaï; A K Erlendsson; I Brandslund
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  105     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-03     Completed Date:  1997-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  650-4     Citation Subset:  IM    
Affiliation:
Department of Medicine, Vejle County Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Complement Activation*
Complement C3d / analysis
Female
Humans
Hypotension / etiology*
Infusions, Intravenous
Male
Middle Aged
Myocardial Infarction / therapy*
Streptokinase / adverse effects*
Chemical
Reg. No./Substance:
80295-45-0/Complement C3d; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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