| Streptokinase after late failure of reconstructive surgery for peripheral arteriosclerosis. | |
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MedLine Citation:
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PMID: 7228888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After the failure of reconstructive surgery for arterial occlusions of the lower limbs, 25 patients with severe ischemia were treated with streptokinase (SK) to avoid amputation of the limbs and sometimes death, in the absence of any other possible treatment. In 16 subjects, thrombolysis, assessed by the Doppler ultrasound technique, occurred rapidly; in 12 cases, SK combined with surgery or with symptomatic medical treatment gave good results saving limbs and improving the quality of life. Three of the 16 patients died from a cerebral vascular accident which occurred before the 10th hour. Whatever the type and the number of surgical operations performed before the use of SK, the indications and the results of the treatment are governed by the condition of the vascular tree below the arterial lesions. SK seems to be justified in endarterectomy or venous grafts with severe ischemia less than two months old. For dacron by-passes, the possibility of prosthesis dissection makes SK debatable in spite of frequent lysis. In axillofemoral by-passes, the risk of embolism of the upper limbs makes the use of SK inadvisable. |
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Authors:
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J M Husson; J N Fiessinger; M Aiach; J M Cormier; E Housset |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of cardiovascular surgery Volume: 22 ISSN: 0021-9509 ISO Abbreviation: J Cardiovasc Surg (Torino) Publication Date: 1981 Mar-Apr |
Date Detail:
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Created Date: 1981-07-23 Completed Date: 1981-07-23 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0066127 Medline TA: J Cardiovasc Surg (Torino) Country: ITALY |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteriosclerosis / drug therapy*, surgery Female Humans Leg Male Middle Aged Streptokinase / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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