Document Detail


Streptococcus pneumoniae mycotic aortic aneurysm after allogeneic bone marrow transplantation.
MedLine Citation:
PMID:  12394853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Streptococcus pneumoniae (SP) is a common cause of community-acquired pneumonia and accounts for up to 30% of all cases of pneumonia. Patients with chronic graft-versus-host-disease (GvHD) after allogeneic bone marrow transplantation (BMT) have a high susceptibility to SP infections. So far, mycotic aneurysm resulting from SP has not been reported after BMT. METHODS: We report on a patient with extensive, chronic GvHD who developed low back pain 22 months after allogeneic BMT. RESULTS: Computed tomography of the abdomen displayed mycotic, saccular aneurysmatic enlargement of the infrarenal aorta, with leakage of contrast medium into the aneurysm. The aneurysm was resected, and the defect was closed with an autologous patch from the internal iliac artery. Bacteriologic samples from the abscess grew SP. The patient recovered uneventfully. CONCLUSIONS: This observation confirms the importance of pneumococcal prophylaxis after BMT and suggests that an aggressive diagnostic approach should always be considered in patients with chronic GvHD, even if they present with nonspecific symptoms.
Authors:
W Rabitsch; S A Brugger; W Trubel; F Keil; H T Greinix; P Kalhs
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  74     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-25     Completed Date:  2002-11-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1048-50     Citation Subset:  IM    
Affiliation:
Department of Medicine I, Bone Marrow Transplantation Unit, University of Vienna, Austria. Werner.Rabitsch@akh-wien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Aneurysm, Infected / complications,  etiology*,  radiography,  surgery
Aortic Aneurysm / complications,  etiology*,  radiography,  surgery
Bone Marrow Transplantation / adverse effects*
Chronic Disease
Female
Graft vs Host Disease / complications
Humans
Pneumococcal Infections / complications,  etiology*,  radiography,  surgery
Tomography, X-Ray Computed
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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