| Streptococcus pneumoniae induces human β-defensin-2 and -3 in human lung epithelium. | |
| | |
MedLine Citation:
|
PMID: 22296408 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
ABSTRACT Streptococcus pneumoniae is an important causative agent of pneumonia in humans. Pulmonary epithelial surfaces constitutes not only a mechanical barrier against invading pathogens but also essentially contribute to innate immunity by producing antimicrobial peptides such as human β-defensin-2 (hBD-2) and -3 (hBD-3). In this study the authors demonstrated that pneumococci induced hBD-2 and hBD-3 expression in human pulmonary epithelial cells. Further analysis indicated an essential role of Toll-like receptor 2 (TLR2) for the expression of both peptides in infected pulmonary epithelial cells. Whereas the hBD-2 release was controlled by the phosphoinositide 3-kinase (PI3K) and the transcription factor nuclear factor kappa B (NF-κB), hBD-3 was triggered via the c-Jun N-terminal kinase (JNK)-activator protein 1 (AP-1) pathway. Additionally, the authors showed that exogenous hBD-2 as well as hBD-3 elicited a strong antimicrobial effect on S. pneumoniae. Thus, differential regulation of the expression of hBD-2 and hBD-3 might play an important role in pneumococci pneumonia. |
| | |
Authors:
|
Stefanie Scharf; Janine Zahlten; Kolja Szymanski; Stefan Hippenstiel; Norbert Suttorp; Philippe Dje N'guessan |
Related Documents
:
|
23451058 - Identification of novel ar-targeted micrornas mediating androgen signalling through cri... 16042788 - Prediction of the general transcription factors associated with rna polymerase ii in pl... 22411638 - Fgf and bmp signaling are required for specifying pre-chondrogenic identity in neural c... 23259668 - Employment of gene expression profiling to identify transcriptional regulators of hepat... 11607818 - Common themes in the pathogenesis of acute myeloid leukemia. 20188788 - Amino acid regulation of mammalian gene expression in the intestine. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Experimental lung research Volume: 38 ISSN: 1521-0499 ISO Abbreviation: Exp. Lung Res. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: England |
Other Details:
|
Languages: eng Pagination: 100-10 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine/Infectious Diseases and Pulmonary Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics.
Next Document: Silver as an Example of the Applications of Photochemistry to the Synthesis and Uses of Nanomaterial...