Document Detail

Streptococcus bovis endocarditis and its association with chronic liver disease: an underestimated risk factor.
MedLine Citation:
PMID:  15156477     Owner:  NLM     Status:  MEDLINE    
Clinical and epidemiological characteristics of Streptococcus bovis endocarditis were prospectively studied among 199 patients with definite endocarditis. Thirty patients (15.1%) had S. bovis endocarditis. Compared with patients with non-S. bovis endocarditis, these 30 patients were older (mean age, 58.6+/-12.4 years vs. 46.0+/-17.0 years; P<.001) and had higher rates of bivalvular involvement (43.3% vs. 7.7%; P<.001), embolism (73.3% vs. 40.2%; P=.002), and diskitis (23.3% vs. 0.6% P<.001). In patients with S. bovis biotype I (S. bovis I) endocarditis, advanced liver disease was present in 56.7%, compared with 15.3% of patients with non-S. bovis endocarditis (P<.001), and colonic adenoma was present in 46.7%. The in-hospital mortality rate (16.7%) was correlated with delayed diagnosis and advanced liver diseases. In our city, S. bovis I endocarditis is frequently correlated with liver diseases; diskitis may be the first sign of the disease.
M F Tripodi; L E Adinolfi; E Ragone; E Durante Mangoni; R Fortunato; D Iarussi; G Ruggiero; R Utili
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-04-28
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  38     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-24     Completed Date:  2004-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1394-400     Citation Subset:  IM    
Department of Internal Medicine, Second University of Naples, I-80135 Naples, Italy.
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Chronic Disease
Colonic Neoplasms
Discitis / etiology*
Embolism / etiology
Endocarditis, Bacterial / complications*,  mortality
Gastrointestinal Diseases / complications
Liver Diseases / complications*,  epidemiology
Liver Function Tests
Middle Aged
Risk Factors*
Streptococcal Infections / complications*,  mortality
Streptococcus bovis* / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents
Comment In:
Clin Infect Dis. 2004 Nov 15;39(10):1551; author reply 1551   [PMID:  15546102 ]

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