Document Detail

Strenuous, intensive, long-term exercise does not prevent or delay the onset of Huntington's disease.
MedLine Citation:
PMID:  16824703     Owner:  NLM     Status:  MEDLINE    
Recent work in mice has suggested that an enriched environment can delay disease onset in models of Huntington's disease (HD). The component of an enriched environment most likely able to be translated to humans is increased exercise. But here I note that a recently reported case of HD in a marathon runner who had, for many years before becoming symptomatic with HD, been running at an advanced amateur/semiprofessional level, suggests that in humans exercise is not able to prevent or even delay onset of HD. In general study of marathon runners may be useful to study if exercise can prevent or delay onset of genetic diseases.
Eric Lewin Altschuler
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Publication Detail:
Type:  Journal Article     Date:  2006-07-07
Journal Detail:
Title:  Medical hypotheses     Volume:  67     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-02     Completed Date:  2007-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  1429-30     Citation Subset:  IM    
Department of Physical Medicine & Rehabilitation, University of Medicine & Dentistry of New Jersey, 30 Bergen Street, ADMC 1, Suite 101, Newark, NJ 07101, United States.
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MeSH Terms
Age of Onset
Disease Models, Animal
Disease Progression
Exercise / physiology*
Huntington Disease / etiology*,  pathology,  physiopathology*
Models, Biological*
Physical Endurance / physiology*

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