| Strenuous, intensive, long-term exercise does not prevent or delay the onset of Huntington's disease. | |
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MedLine Citation:
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PMID: 16824703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent work in mice has suggested that an enriched environment can delay disease onset in models of Huntington's disease (HD). The component of an enriched environment most likely able to be translated to humans is increased exercise. But here I note that a recently reported case of HD in a marathon runner who had, for many years before becoming symptomatic with HD, been running at an advanced amateur/semiprofessional level, suggests that in humans exercise is not able to prevent or even delay onset of HD. In general study of marathon runners may be useful to study if exercise can prevent or delay onset of genetic diseases. |
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Authors:
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Eric Lewin Altschuler |
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Publication Detail:
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Type: Journal Article Date: 2006-07-07 |
Journal Detail:
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Title: Medical hypotheses Volume: 67 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2006 |
Date Detail:
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Created Date: 2006-10-02 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 1429-30 Citation Subset: IM |
Affiliation:
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Department of Physical Medicine & Rehabilitation, University of Medicine & Dentistry of New Jersey, 30 Bergen Street, ADMC 1, Suite 101, Newark, NJ 07101, United States. eric.altschuler@umdnj.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Animals Disease Models, Animal Disease Progression Exercise / physiology* Humans Huntington Disease / etiology*, pathology, physiopathology* Mice Models, Biological* Physical Endurance / physiology* |
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