Document Detail

Strength vs aerobic training in children with cystic fibrosis: a randomized controlled trial.
MedLine Citation:
PMID:  15486384     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: Exercise has the potential to improve the ability of a patient with cystic fibrosis (CF) to cope with the physical demands of everyday life, and may improve prognosis. The purpose of this study was to compare the effects of a home-based, semi-supervised, upper-body strength-training regimen with a similarly structured aerobic training regimen. DESIGN: Data were collected during a 1-year randomized clinical trial. SETTING: Counselors conducted in-home visits with the participants once per week for the first 8 weeks followed by monthly visits for the remainder of the study. PATIENTS: Sixty-seven patients with CF, aged 8 to 18 years, participated in the trial. INTERVENTION: Participants in both exercise conditions were encouraged to exercise at least three times per week for 1 year. Each child in the aerobic group was given a stair-stepping machine, and each child in the upper-body strength training group was given an upper-body-only weight-resistance machine. MEASURES AND RESULTS: Aerobic fitness, pulmonary function, quality of life, and strength were measured at baseline, at 6 months, and at 12 months. Strength training increased the maximum weight lifted for biceps curls significantly more than aerobic training (p < 0.02). However, this differential did not remain significant after control for increase in height. Both training procedures were associated with increased strength (p < 0.002) and physical work capacity (PWC) [p < 0.033]. CONCLUSIONS: We concluded that strength and aerobic training may increase upper-body strength, and that both types of training may increase PWC for children with CF. Future trials should be conducted with no-training control subjects and larger samples to increase statistical power.
David M Orenstein; Melbourne F Hovell; Mary Mulvihill; Kristen K Keating; C Richard Hofstetter; Sheryl Kelsey; Kimberly Morris; Patricia A Nixon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  126     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-15     Completed Date:  2004-12-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1204-14     Citation Subset:  AIM; IM    
Center for Behavioral Epidemiology and Community Health, 9245 Sky Park Court, Suite 230, San Diego, CA 92123, USA.
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MeSH Terms
Cystic Fibrosis / rehabilitation*
Exercise Therapy* / methods
Physical Fitness
Prospective Studies
Quality of Life
Respiratory Function Tests
Treatment Outcome
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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