Document Detail


Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial.
MedLine Citation:
PMID:  21424279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Targeted exercise training could reduce risk factors for fracture and obesity-related diseases that increase from breast cancer treatment, but has not been sufficiently tested. We hypothesized that progressive, moderate-intensity resistance + impact training would increase or maintain hip and spine bone mass, lean mass and fat mass and reduce bone turnover compared to controls who participated in a low-intensity, non-weight bearing stretching program. We conducted a randomized, controlled trial in 106 women with early stage breast cancer who were >1 year post-radiation and/or chemotherapy, ≥ 50 years of age at diagnosis and postmenopausal, free from osteoporosis and medications for bone loss, resistance and impact exercise naïve, and cleared to exercise by a physician. Women were randomly assigned to participate in 1 year of thrice-weekly progressive, moderate-intensity resistance + impact (jump) exercise or in a similar frequency and length control program of progressive, low-intensity stretching. Primary endpoints were bone mineral density (BMD; g/cm²) of the hip and spine and whole body bone-free lean and fat mass (kg) determined by DXA and biomarkers of bone turnover-serum osteocalcin (ng/ml) and urinary deoxypyrodiniline cross-links (nmol/mmolCr). Women in the resistance + impact training program preserved BMD at the lumbar spine (0.47 vs. -2.13%; P = 0.001) compared to controls. The resistance + impact group had a smaller increase in osteocalcin (7.0 vs. 27%, P = 0.03) and a larger decrease in deoxypyrodinoline (-49.9 vs. -32.6%, P = 0.06) than controls. Increases in lean mass from resistance + impact training were greatest among women currently taking aromatase inhibitors compared to controls not on this therapy (P = 0.01). Our combined program of resistance + impact exercise reduced risk factors for fracture among postmenopausal breast cancer survivors (BCS) and may be particularly relevant for BCS on aromatase inhibitors (AIs) because of the additional benefit of exercise on muscle mass that could reduce falls.
Authors:
Kerri M Winters-Stone; Jessica Dobek; Lillian Nail; Jill A Bennett; Michael C Leo; Arpana Naik; Anna Schwartz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-19
Journal Detail:
Title:  Breast cancer research and treatment     Volume:  127     ISSN:  1573-7217     ISO Abbreviation:  Breast Cancer Res. Treat.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-04     Completed Date:  2011-08-16     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8111104     Medline TA:  Breast Cancer Res Treat     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  447-56     Citation Subset:  IM    
Affiliation:
School of Nursing, Oregon Health & Science University, Portland, OR 97239, USA. wintersk@ohsu.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Body Weights and Measures
Bone Density / physiology
Breast Neoplasms / complications*
Female
Humans
Middle Aged
Osteoporosis, Postmenopausal / complications*,  therapy*
Resistance Training*
Survivors*
Grant Support
ID/Acronym/Agency:
1R01 CA120123/CA/NCI NIH HHS; R01 CA120123/CA/NCI NIH HHS; R01 CA120123-03/CA/NCI NIH HHS; UL1 RR024140/RR/NCRR NIH HHS
Comments/Corrections
Erratum In:
Breast Cancer Res Treat. 2011 Jun;127(2):457

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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