Document Detail


Strength reductions from trabecular destruction within thoracic vertebrae.
MedLine Citation:
PMID:  8504224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An in vitro model of metastatic lesions in thoracic vertebrae was used to determine if the reduction in vertebral cross-sectional area could be used to predict the associated strength reduction. Defects, entirely within the trabecular bone, were created in alternating vertebrae of unembalmed human thoracic spines. The adjacent vertebrae were tested intact and served as controls. Defect size was determined as the cross-sectional area of the defect divided by the nominal cross-sectional area of the vertebral body midplane. Vertebrae were tested to failure using combined axial-flexion loads. For each spine, a linear regression was determined between the cross sectional area of the superior endplate and the load at failure for the intact vertebrae. The intact strength of bodies with defects was estimated from this regression. The normalized strength of thoracic vertebrae with trabecular defects was linearly related to the reduction in cross-sectional area (normalized failure load = 1.0-Ad/Ai, r2 = 0.51; Ad = cross-sectional area of defect; and Ai = intact cross-sectional area at midplane). The data suggest that the strength reduction due to lytic defects within the centrum of thoracic vertebrae is proportional to the cross-sectional area of bone resorbed.
Authors:
D P McGowan; J A Hipp; T Takeuchi; A A White; W C Hayes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of spinal disorders     Volume:  6     ISSN:  0895-0385     ISO Abbreviation:  J Spinal Disord     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-02     Completed Date:  1993-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8904842     Medline TA:  J Spinal Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-6     Citation Subset:  IM    
Affiliation:
Department of Orthopaedic Surgery, Charles A. Dana Research Institute, Beth Israel Hospital, Boston, Massachusetts 02215.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Stress, Mechanical*
Thoracic Vertebrae / abnormalities,  physiopathology*
Grant Support
ID/Acronym/Agency:
CA40211-05/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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