| Strength of the human mixed lymphocyte reaction (MLR) and its suppression by azathioprine or 6-mercaptopurine. | |
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MedLine Citation:
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PMID: 3156615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Azathioprine (36 microM) had a significantly (P less than 0.00003) greater inhibitory effect on human MLR responses below 20,000 counts/min than on responses above 20,000 counts/min. In contrast, 6-mercaptopurine (100 microM) had a similar suppressive effect on MLR responses below and above 20,000 counts/min suggesting it has a different mode of action to azathioprine. |
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Authors:
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S A Al-Safi; J L Maddocks |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 19 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-05-09 Completed Date: 1985-05-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 105-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Mercaptopurine
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pharmacology* Azathioprine / pharmacology* Graft Survival / drug effects* Humans Kidney Transplantation Lymphocyte Culture Test, Mixed |
| Chemical | |
Reg. No./Substance:
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446-86-6/Azathioprine; 50-44-2/6-Mercaptopurine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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