| Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. | |
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MedLine Citation:
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PMID: 17559698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anthocyanins are natural dietary pigments with a wide array of biological properties that are possibly involved in the prevention of various diseases. These properties depend on their absorption and metabolism in the body. In the present study we first examined the gastric and intestinal absorption of pelargonidin 3-glucoside (Pg 3-glc) using rat in situ models. A high proportion of Pg 3-glc was rapidly absorbed from both the stomach (23 %) and small intestine (24 %). Its metabolism was further studied by feeding rats during 8 d with a diet enriched in freeze-dried strawberries. Only low amounts of total anthocyanins were recovered in 24 h urine (0.163 (SEM 0.013) % of ingested anthocyanins; n 8). Strawberry anthocyanins were analysed in urine by HPLC-electrospray ionisation-tandem MS. Similar proportions of intact glycosides (about 53 %) and glucuronidated metabolites (about 47 %) were found. Pg 3-glc was thus glucuronidated to a larger extent than cyanidin 3-glucoside. These results highlight the influence of the aglycone structure on anthocyanin metabolism. |
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Authors:
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Catherine Felgines; Odile Texier; Catherine Besson; Bernard Lyan; Jean-Louis Lamaison; Augustin Scalbert |
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Publication Detail:
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Type: Journal Article Date: 2007-06-11 |
Journal Detail:
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Title: The British journal of nutrition Volume: 98 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-27 Completed Date: 2008-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1126-31 Citation Subset: IM |
Affiliation:
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Université Clermont 1, UFR Pharmacie, Laboratoire de Pharmacognosie, 28 Place Henri Dunant, BP 38, F-63001 Clermont-Ferrand Cedex 1, France. catherine.felgines@u-clermont.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthocyanins / administration & dosage, urine* Chromatography, High Pressure Liquid Flavonoids / administration & dosage, urine* Fragaria / chemistry* Glucuronides / metabolism Intestinal Absorption / physiology Male Perfusion Rats Rats, Wistar Stomach / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anthocyanins; 0/Flavonoids; 0/Glucuronides; 18466-51-8/pelargonidin-3-glucoside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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