| Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome. | |
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MedLine Citation:
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PMID: 20797478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Strawberries have been reported to be potent antioxidants and reduce cardiovascular risk factors, such as elevated blood pressure, hyperglycemia, dyslipidemia, and inflammation in limited studies. We hypothesized that freeze-dried strawberry supplementation will improve blood pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome, thereby lowering cardiovascular risk factors in these subjects. Twenty-seven subjects with metabolic syndrome (2 males and 25 females; body mass index, 37.5 +/- 2.15 kg/m(2); age, 47.0 +/- 3.0 years [means +/- SE]) consumed 4 cups of freeze-dried strawberry beverage (50 g freeze-dried strawberries approximately 3 cups fresh strawberries) or equivalent amounts of fluids (controls, 4 cups of water) daily for 8 weeks in a randomized controlled trial. Anthropometrics and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screen and 8 weeks of the study. Strawberry supplementation significantly decreased total and low-density lipoprotein cholesterol (5.8 +/- 0.2 to 5.2 +/- 0.2 mmol/L and 3.5 +/- 0.2 to 3.1 +/- 0.1 mmol/L, respectively [means +/- SE], P < .05) and small low-density lipoprotein particles using nuclear magnetic resonance-determined lipoprotein subclass profile vs controls at 8 weeks (794.6 +/- 94.0 to 681.8 +/- 86.0 nmol/L [means +/- SE], P < .05). Strawberry supplementation further decreased circulating levels of vascular cell adhesion molecule-1 vs controls at 8 weeks (272.7 +/- 17.4 to 223.0 +/- 14.0 ng/mL [means +/- SE], P < .05). Serum glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, and waist circumference were not affected. Thus, short-term freeze-dried strawberry supplementation improved selected atherosclerotic risk factors, including dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome, and these results need confirmation in future trials. |
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Authors:
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Arpita Basu; Dong Xu Fu; Marci Wilkinson; Brandi Simmons; Mingyuan Wu; Nancy M Betts; Mei Du; Timothy J Lyons |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 30 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-12-10 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 462-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Nutritional Sciences, 301 Human Environmental Sciences, Oklahoma State University, Stillwater, OK 74078-6141, USA. arpita.basu@okstate.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / administration & dosage Atherosclerosis / blood, prevention & control* Beverages Biological Markers Cholesterol / blood Cholesterol, LDL / blood Female Food, Preserved Fragaria* / chemistry Freeze Drying Fruit* / chemistry Humans Male Metabolic Syndrome X / drug therapy* Middle Aged Particle Size Phytotherapy Vascular Cell Adhesion Molecule-1 / blood |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR014467-05/RR/NCRR NIH HHS; M01-RR14467/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Cholesterol, LDL; 0/Vascular Cell Adhesion Molecule-1; 57-88-5/Cholesterol |
| Comments/Corrections | |
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