Document Detail

Stratum corneum maturation. A review of neonatal skin function.
MedLine Citation:
PMID:  14976382     Owner:  NLM     Status:  MEDLINE    
The importance of the stratum corneum and its barrier function for infants, especially for newborns, is clinically evident. Research regarding the maturation of the stratum corneum in neonates, i.e. when full barrier function is obtained, has produced varying results. Based on transepidermal water loss and percutaneous absorption studies, term infants seem to possess stratum corneum with adult barrier properties. Additionally, postnatal life is thought to accelerate stratum corneum maturation, so that even preterm infants have barrier function similar to term infants at 2-3 weeks of gestational age. However, a look at other parameters, such as skin thickness, skin pH and stratum corneum hydration, shows that neonatal skin is always adjusting to the extrauterine environment in contrast to the steady state of adult skin. This suggests that barrier stabilization may be dependent on achieving a balance between different parameters. However, it is still in question, which parameters, what balance and what timing. This paper provides an up-to-date overview on the neonatal skin barrier based on the review of current literature.
Y B Chiou; U Blume-Peytavi
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Skin pharmacology and physiology     Volume:  17     ISSN:  1660-5527     ISO Abbreviation:  Skin Pharmacol Physiol     Publication Date:    2004 Mar-Apr
Date Detail:
Created Date:  2004-02-20     Completed Date:  2004-12-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101188418     Medline TA:  Skin Pharmacol Physiol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  57-66     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Department of Dermatology and Allergy, Center for Clinical Research on Hair and Skin Physiology, Charité University of Medicine Berlin, Berlin, Germany.
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MeSH Terms
Epidermis / cytology,  growth & development*,  metabolism*
Infant, Newborn
Skin Physiological Phenomena*

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