| Stratum corneum hydration and flexibility are useful parameters to indicate clinical severity of congenital ichthyosis. | |
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MedLine Citation:
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PMID: 16026584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine any correlation between the stratum corneum barrier function and the phenotypic severity of congenital ichthyosis, we studied stratum corneum hydration, flexibility, thickness and transepidermal water loss (TEWL) in patients with congenital ichthyosis. Seven patients with congenital ichthyosis aged 2-46 years and age-matched controls were included in the present study. We divided seven patients into two groups; patients with non-bullous type (non-bullous congenital ichthyosiform erythroderma patients) and patients with the bullous type of congenital ichthyosis (bullous congenital ichthyosiform erythroderma and ichthyosis bullosa of Siemens). Stratum corneum hydration, thickness and flexibility were measured using a Corneometer ASA-M2. The stratum corneum thickness was also examined using a skin biopsy technique. TEWL was measured using Evaporimeter AS-TW1. The clinical severity of ichthyosis phenotype was evaluated using a visual analogue scale (VAS). Stratum corneum hydration and flexibility were significantly reduced in both congenital ichthyosis patient groups. Stratum corneum thickness was significantly increased in both groups. In the patient group with non-bullous congenital ichthyosis, significant negative correlations were confirmed between the VAS score and stratum corneum hydration and between the VAS score and flexibility. A significant, positive correlation was also observed between the VAS score and stratum corneum thickness. There was a positive correlation between the VAS score and TEWL on both the extensor and flexor sides of the forearm and back. We conclude that stratum corneum hydration, flexibility and thickness measured by the corneometer, and TEWL on the arm may be a useful indicator of the severity of ichthyosis phenotype. |
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Authors:
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Yuki Tomita; Masashi Akiyama; Hiroshi Shimizu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental dermatology Volume: 14 ISSN: 0906-6705 ISO Abbreviation: Exp. Dermatol. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-19 Completed Date: 2005-10-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 619-24 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. y-tomita@med.hokudai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy Child Child, Preschool Epidermis / pathology, physiology* Female Humans Hyperkeratosis, Epidermolytic / diagnosis*, pathology Ichthyosis / diagnosis*, pathology* Ichthyosis, Lamellar / diagnosis*, pathology Male Middle Aged Phenotype Skin / pathology Skin Absorption Skin Diseases / diagnosis Skin Physiological Phenomena |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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