| Stratum corneum hydration and skin surface pH in patients with atopic dermatitis. | |
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MedLine Citation:
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PMID: 22185924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atopic dermatitis (AD) is a chronically relapsing skin disease with genetic predisposition, which occurs most frequently in preschool children. It is considered that dryness and pruritus, which are always present in AD, are in correlation with degradation of the skin barrier function. Measurement of hydration and pH value of the stratum corneum is one of the noninvasive methods for evaluation of skin barrier function. The aim of the study was to assess skin barrier function by measuring stratum corneum hydration and skin surface pH of the skin with lesions, perilesional skin and uninvolved skin in AD patients, and skin in a healthy control group. Forty-two patients were included in the study: 21 young and adult AD patients and 21 age-matched healthy controls. Capacitance, which is correlated with hydration of stratum corneum and skin surface pH were measured on the forearm in the above areas by SM810/CM820/pH900 combined units (Courage AND Khazaka, Germany). The mean value of water capacitance measured in AD patients was 44.1 ± 11.6 AU (arbitrary units) on the lesions, 60.2 ± 12.4 AU on perilesional skin and 67.2 ± 8.8 AU on uninvolved skin. In healthy controls, the mean value was 74.1 ± 9.2 AU. The mean pH value measured in AD patients was 6.13 ± 0.52 on the lesions, 5.80 ± 0.41 on perilesional skin, and 5.54 ± 0.49 on uninvolved skin. In control group, the mean pH of the skin surface was 5.24 ± 0.40. The values of both parameters measured on lesional skin were significantly different (capacitance decreased and pH increased) from the values recorded on perilesional skin and uninvolved skin. The same held for the relation between perilesional and uninvolved skin. According to study results, the uninvolved skin of AD patients had significantly worse values of the measured parameters as compared with control group. The results of this study suggested the skin barrier function to be degraded in AD patients, which is specifically expressed in lesional skin. |
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Authors:
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Tanja Knor; Ajša Meholjić-Fetahović; Aida Mehmedagić |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermatovenerologica Croatica : ADC Volume: 19 ISSN: 1847-6538 ISO Abbreviation: Acta Dermatovenerol Croat Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-21 Completed Date: 2012-05-08 Revised Date: 2012-08-31 |
Medline Journal Info:
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Nlm Unique ID: 9433781 Medline TA: Acta Dermatovenerol Croat Country: Croatia |
Other Details:
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Languages: eng Pagination: 242-7 Citation Subset: IM |
Affiliation:
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University Department of Dermatovenereology, Sarajevo University Clinical Center, Bosnia and Herzegovina. knor@bih.net.ba |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Dehydration / physiopathology Dermatitis, Atopic / physiopathology* Female Humans Hydrogen-Ion Concentration Male Skin / chemistry*, physiopathology* Water Loss, Insensible / physiology Young Adult |
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