| Strategy for treatment of nonerosive reflux disease in Asia. | |
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MedLine Citation:
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PMID: 18506915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The paper is to review the clinical and pathophysiologic differences between of nonerosive reflux disease (NERD) and reflux esophagitis (RE), and to propose a treatment strategy for NERD, especially for patients in Asia. A Medline search was performed regarding the clinical and pathophysiologic differences between NERD and RE, and treatment of NERD and RE. The characteristics of NERD patients in Asia are as follows: (1) high proportion of female patients, (2) low frequency of hiatal hernia, (3) high frequency of H pylori infection, (4) severe glandular atrophy of the gastric mucosa, and (5) frequent resistance to proton pump inhibitor (PPI) therapy. In Asian NERD patients, exposure of the esophagus to acid is not increased, and esophageal motility is normal. These characteristics are similar to those of patients in Western countries. Our recommended first-choice treatment is administration of PPI in combination with a prokinetic agent. However, at present, because there is limited evidence regarding effective treatments for NERD, it is best to try several different treatment strategies to find the best treatment for each patient. |
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Authors:
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Toru Hiyama; Masaharu Yoshihara; Shinji Tanaka; Ken Haruma; Kazuaki Chayama |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 14 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-28 Completed Date: 2008-08-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 3123-8 Citation Subset: IM |
Affiliation:
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Health Service Center, Hiroshima University, 1-7-1 Kagamiyama, Higashihiroshima 739-8521, Japan. tohiyama@hiroshima-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asia Atrophy Drug Resistance Esophagitis, Peptic / etiology, pathology, physiopathology Esophagus / drug effects*, pathology, physiopathology Female Gastric Mucosa / microbiology, pathology Gastroesophageal Reflux / drug therapy*, etiology, pathology, physiopathology Gastrointestinal Agents / therapeutic use* Helicobacter Infections / complications, microbiology Helicobacter pylori Hernia, Hiatal / complications Humans Male Middle Aged Practice Guidelines as Topic Proton Pump Inhibitors / therapeutic use Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 0/Proton Pump Inhibitors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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