| Strategy for preventing vertical transmisssion of HIV : Bombay experience. | |
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MedLine Citation:
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PMID: 11224577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy of an interventional regime to reduce the perinatal mode of transmission of human immunodeficiency virus (HIV). DESIGN: Prospective. SETTING: Perinatal HIV clinic at a university affiliated maternity hospital. SUBJECT & METHODS: After adequate counseling, consenting HIV positive women were offered perinatal intervention: (i) administration of 400 mg of zidovudine (AZT) per day for the last 6 weeks of the antenatal period; (ii) delivery by elective Caesarian section before rupture of membrances; (iii) oral AZT powder in the dose of 8 mg per kilogram daily to the infant for the first 6 weeks of life; and (iv) avoidance of breast milk. The infants were scheduled for regular follow-up for at least 18 months. A definitive diagnosis of infectivity in the infant was ascertained by two positive enzyme-linked immunosorbent assays (ELISA) at the age of 9 months and between 15 to 18 months. RESULTS: Of the 107 mother-infant pairs enrolled, 22 infants were lost to follow-up, 15 were under 18 months of age at the time of this analysis and 2 infants died without a diagnosis. Of the remaining 68 infants followed up, 4 tested HIV positive at 18 months. Of the 229 women-infant pairs who did not receive perinatal intervention, 55 infants followed up to 15-18 months were found to be infected. CONCLUSION: This interventional strategy significantly reduced the mother to child transmission of HIV. However, the results need to be substantiated by larger studies. |
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Authors:
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R H Merchant; K Damania; I S Gilada; R V Bhagwat; J S Karkare; J S Oswal; S R Merchant; S Changedia |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian pediatrics Volume: 38 ISSN: 0019-6061 ISO Abbreviation: Indian Pediatr Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-08-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 132-8 Citation Subset: IM |
Affiliation:
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Nowrosjee Wadia Maternity Hospital, Acharya Dhonde Marg, Parel, Mumbai 400 012, India. deandoc2000@yahoo.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-HIV Agents / therapeutic use* Female HIV Infections / drug therapy*, transmission Humans India Infectious Disease Transmission, Vertical / prevention & control* Pregnancy Pregnancy Complications, Infectious / drug therapy* Prospective Studies Zidovudine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 30516-87-1/Zidovudine |
| Comments/Corrections | |
Comment In:
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Indian Pediatr. 2001 Jun;38(6):680-3; author reply 684-5
[PMID:
11418741
]
Indian Pediatr. 2001 Jun;38(6):683-4; author reply 684-5 [PMID: 11418742 ] |
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