| Strategies to reduce bleeding among patients with ischemic heart disease treated with antiplatelet therapies. | |
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MedLine Citation:
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PMID: 19695364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antiplatelet therapy is the cornerstone of management in acute coronary syndromes (ACS) and percutaneous coronary intervention. Combination therapy with aspirin and clopidogrel reduces the risk of death, myocardial infarction, or stroke in ACS but increases the risk of major bleeding, which studies indicate is 1%-4% higher when clopidogrel is added to aspirin. Given the association between bleeding and adverse outcomes, minimizing bleeding risk is a clinical priority. This review outlines strategies to reduce both acute and chronic bleeding risk with aspirin and clopidogrel and focuses on dosing of concomitant therapies, vascular access techniques, and mitigating the bleeding risk associated with coronary artery bypass grafting surgery. |
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Authors:
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Sunil V Rao |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The American journal of cardiology Volume: 104 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-21 Completed Date: 2009-09-15 Revised Date: 2010-07-07 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 60C-3C Citation Subset: AIM; IM |
Affiliation:
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Duke Clinical Research Institute, Durham, NC 27705, USA. sunil.rao@duke.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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therapy* Administration, Oral Humans Myocardial Revascularization / adverse effects Platelet Aggregation Inhibitors / administration & dosage, adverse effects* Postoperative Hemorrhage / etiology*, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors |
| Comments/Corrections | |
Erratum In:
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Am J Cardiol. 2010 Jul 15;106(2):295 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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