| Strategies to prevent and treat preeclampsia: evidence from randomized controlled trials. | |
| | |
MedLine Citation:
|
PMID: 15529296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Preeclampsia-eclampsia is a major cause of morbidity and mortality in mothers, fetuses, and neonates worldwide, most devastating in developing nations. Its cause is still uncertain, and many controversies exist concerning its management. The World Health Organization is aware of this and is coordinating a series of systematic reviews that focus on the etiology and the best strategies for the screening, prevention, and treatment of preeclampsia. This article summarizes results from systematic reviews of randomized trials to prevent and manage preeclampsia. There is a prophylactic role of modest magnitude for low-dose aspirin but the number to treat (90 women) to avoid one case of preeclampsia still is considered high. Antioxidant and calcium supplement trials remain to be completed before firm conclusions can be rendered on their efficacy for prevention. Magnesium sulfate is effective in preventing and treating eclampsia, while severe hypertension (with or without proteinuria) requires drug therapy, but there appears to be no benefits to treating mild to moderate hypertension without proteinuria in pregnancy. Finally, our review focuses on the quality of data reviewed, suggesting the need for better evidence, and discusses the use of systematic reviews as a strategy to focus future research on this important area of reproductive medicine. |
| | |
Authors:
|
José Villar; Edgardo Abalos; Juan M Nardin; Mario Merialdi; Guillermo Carroli |
Related Documents
:
|
18515046 - Overwhelming heterogeneity in systematic reviews of observational anti-epileptic studies. 20115966 - Postmaneuver restrictions in benign paroxysmal positional vertigo: an individual patien... 19286876 - Structured abstracts: do they improve citation retrieval from dental journals? 17636736 - Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiot... 16940886 - Efficacy of lower than standard doses of pancreatic enzyme supplementation therapy duri... 21506206 - Paternal depression: an examination of its links with father, child and family function... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Seminars in nephrology Volume: 24 ISSN: 0270-9295 ISO Abbreviation: Semin. Nephrol. Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-11-05 Completed Date: 2005-09-13 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
|
Languages: eng Pagination: 607-15 Citation Subset: IM |
Affiliation:
|
Special Programme of Research in Human Reproduction, World Health Organization, Geneva, Switzerland. villarj@who.int |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Female Humans Hypertension / therapy Pre-Eclampsia / prevention & control, therapy* Pregnancy Pregnancy Complications, Cardiovascular / therapy Randomized Controlled Trials as Topic Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Animal models of preeclampsia.
Next Document: Antihypertensive therapy in pregnancy.