Document Detail

Strategies to prevent chronic neonatal lung disease.
MedLine Citation:
PMID:  9007774     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of chronic neonatal lung disease involves the combined iatrogenic insults of oxygen toxicity and barotrauma in addition to lung inflammation. Newer ventilator strategies using smaller tidal volumes (3-7 mL/kg) in order to avoid overdistension, higher positive end-respiratory pressure and lower peak inspiratory pressures decrease barotrauma. Earlier reduction of FiO2 through the use of surfactant, high frequency ventilation and nitric oxide reduce oxygen toxicity. Other measures include careful fluid balance, avoidance of prolonged paralysis and early steroids to decrease inflammation.
M B Schindler
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  32     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-04-11     Completed Date:  1997-04-11     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  477-9     Citation Subset:  IM    
Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children, London, United Kingdom.
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MeSH Terms
Bronchopulmonary Dysplasia / etiology,  prevention & control*
Chronic Disease
Infant, Newborn
Respiration, Artificial / adverse effects,  methods
Respiratory Distress Syndrome, Newborn / complications*,  therapy
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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