Document Detail


Strategies to achieve coronary arterial plaque stabilization.
MedLine Citation:
PMID:  10341840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute coronary syndromes result from fissure, erosion or rupture of a vulnerable atherosclerotic plaque. The characteristics of a vulnerable plaque include a large lipid pool, an abundance of inflammatory cells and mediators, a reduced smooth muscle cell and collagen content and a thin overlying fibrous cap. Potential therapeutic strategies at achieving plaque stabilization have targeted these features. Lipid lowering agents, beta-adrenergic blockers, angiotensin converting enzyme inhibitors and antioxidants have been shown to reduce the incidence of acute coronary syndromes, presumably through plaque stabilization. Matrix metalloproteinase inhibitors as well as macrolide antibiotics and gene therapy approaches show promise in achieving plaque stabilization. The evidence supporting plaque stabilization by these agents and the mechanisms by which these agents stabilize plaques are discussed in detail in this review.
Authors:
R Rabbani; E J Topol
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiovascular research     Volume:  41     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  402-17     Citation Subset:  IM    
Affiliation:
Cleveland Clinic Foundation, Department of Cardiology, OH 44195, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Animals
Anti-Bacterial Agents / therapeutic use
Antilipemic Agents / therapeutic use*
Antioxidants / therapeutic use*
Coronary Artery Disease / therapy*
Female
Gene Therapy
Humans
Macrolides
Male
Metalloendopeptidases / therapeutic use
Myocardial Infarction / prevention & control*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Anti-Bacterial Agents; 0/Antilipemic Agents; 0/Antioxidants; 0/Macrolides; EC 3.4.24.-/Metalloendopeptidases

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