Document Detail


Strategies to reduce relapse after allogeneic hematopoietic cell transplantation in acute myeloid leukemia.
MedLine Citation:
PMID:  23456518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of acute myeloid leukemia (AML) is expected to increase in conjunction with our ageing population. Although it is proving to be a heterogeneous disease process, the only treatment with proven survival benefit for poor risk AML remains allogeneic hematopoietic cell transplant. Although this is presumed to be a curative strategy, many patients relapse after transplant, prompting us to examine various ways that we can improve outcomes. These efforts involve every step of AML diagnostics and therapy, including the intricate processes of conditioning, graft manipulation and immunomodulation. The hope is that improvement in these steps will ultimately improve survival and decrease relapse rates for AML patients after transplant.
Authors:
Raya Mawad; Jack M Lionberger; John M Pagel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hematologic malignancy reports     Volume:  8     ISSN:  1558-822X     ISO Abbreviation:  Curr Hematol Malig Rep     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-21     Completed Date:  2013-10-22     Revised Date:  2013-12-03    
Medline Journal Info:
Nlm Unique ID:  101262565     Medline TA:  Curr Hematol Malig Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  132-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Hematopoietic Stem Cell Transplantation / methods*
Humans
Leukemia, Myeloid, Acute / prevention & control,  therapy*
Recurrence / prevention & control
Remission Induction / methods
Transplantation Conditioning / methods
Transplantation, Homologous
Grant Support
ID/Acronym/Agency:
P01 CA044991/CA/NCI NIH HHS; T32 HL007093/HL/NHLBI NIH HHS
Comments/Corrections

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