Document Detail

Strategies for the prevention of atherosclerotic progression in women.
MedLine Citation:
PMID:  11895578     Owner:  NLM     Status:  MEDLINE    
Atherosclerosis is an inflammatory and fibrotic process that begins early in life in females. The pathogenesis involves the oxidation of the low-density lipoprotein molecule aggravated by smoking, hypertension, lipid abnormalities, and hormonal changes. Risks for progression of atherosclerosis can now be tabulated for the female based on age, cholesterol, smoking, high-density lipoprotein, and systolic blood pressure. During the reproductive years, emphasis should be placed on lifestyle changes, but women at increased risk for diabetes should be aggressively treated with lipid-lowering agents. During the menopausal phase of life, an important consideration is the use of hormone replacement along with lifestyle changes, smoking cessation, blood pressure control, and lipid modification. In the female with established coronary heart disease, standard cardiac medications are indicated along with more aggressive approaches to risk factors and target goals for cholesterol, low-density lipoprotein, and triglycerides. The effect of hormone replacement in established coronary artery disease is uncertain. Therefore, strategies for slowing the progression of atherosclerosis should begin during the reproductive years, with particular emphasis in patients during menopause and in patients with coronary heart disease.
Charles E Rackley
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology in review     Volume:  10     ISSN:  1061-5377     ISO Abbreviation:  Cardiol Rev     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-15     Completed Date:  2002-05-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
Lipid Disorder Center, Division of Cardiology, Georgetown University Medical Center, Washington, DC 20007, USA.
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MeSH Terms
Arteriosclerosis / etiology,  therapy*
Health Behavior
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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