Document Detail

Strategies for the preparation of bifunctional gadolinium(III) chelators.
MedLine Citation:
PMID:  22375102     Owner:  NLM     Status:  Publisher    
The development of gadolinium chelators that can be easily and readily linked to various substrates is of primary importance for the development high relaxation efficiency and/or targeted magnetic resonance imaging (MRI) contrast agents. Over the last 25 years a large number of bifunctional chelators have been prepared. For the most part, these compounds are based on ligands that are already used in clinically approved contrast agents. More recently, new bifunctional chelators have been reported based on complexes that show a more potent relaxation effect, faster complexation kinetics and in some cases simpler synthetic procedures. This review provides an overview of the synthetic strategies used for the preparation of bifunctional chelators for MRI applications.
Luca Frullano; Peter Caravan
Publication Detail:
Journal Detail:
Title:  Current organic synthesis     Volume:  8     ISSN:  1570-1794     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2012-2-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208457     Medline TA:  Curr Org Synth     Country:  -    
Other Details:
Languages:  ENG     Pagination:  535-565     Citation Subset:  -    
Case Western Reserve University. 11100 Euclid Ave Cleveland, OH 44106.
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Grant Support
R01 EB009062-01A1S2//NIBIB NIH HHS; R01 EB009062-03//NIBIB NIH HHS; R21 EB009738-02//NIBIB NIH HHS

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