Document Detail

Strategies for organ level tissue engineering.
MedLine Citation:
PMID:  21197216     Owner:  NLM     Status:  MEDLINE    
The field of tissue engineering has made considerable strides since it was first described in the late 1980s. The advent and subsequent boom in stem cell biology, emergence of novel technologies for biomaterial development and further understanding of developmental biology have contributed to this accelerated progress. However, continued efforts to translate tissue-engineering strategies into clinical therapies have been hampered by the problems associated with scaling up laboratory methods to produce large, complex tissues. The significant challenges faced by tissue engineers include the production of an intact vasculature within a tissue-engineered construct and recapitulation of the size and complexity of a whole organ. Here we review the basic components necessary for bioengineering organs-biomaterials, cells and bioactive molecules-and discuss various approaches for augmenting these principles to achieve organ level tissue engineering. Ultimately, the successful translation of tissue-engineered constructs into everyday clinical practice will depend upon the ability of the tissue engineer to "scale up" every aspect of the research and development process.
Kristine C Rustad; Michael Sorkin; Benjamin Levi; Michael T Longaker; Geoffrey C Gurtner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Organogenesis     Volume:  6     ISSN:  1555-8592     ISO Abbreviation:  Organogenesis     Publication Date:    2010 Jul-Sep
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-05-02     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101253266     Medline TA:  Organogenesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Stanford University, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford, CA, USA.
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MeSH Terms
Organ Culture Techniques*
Tissue Engineering*
Tissue Scaffolds*

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