Document Detail


Strategies for the development of gadolinium-based 'q'-activatable MRI contrast agents.
MedLine Citation:
PMID:  23015370     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The emergence and rapid development of activatable contrast agents (CAs), whose relaxivity changes in response to the variation of a specific marker in the surrounding physiological microenvironment, have expanded the scope of MRI beyond anatomical and functional imaging to also convey information at the cellular and molecular level. The essence of an activatable MRI CA is the difference in relaxivity before and after a change in a physiological variable: the larger the difference, the better the CA. In this review, strategies for the design of activatable gadolinium CAs, with a switching mechanism based on the modulation of hydration (q), sensitive to common variables in the physiological microenvironment, such as pH, light, redox and metal ions, are illustrated and discussed. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Chuqiao Tu; Angelique Y Louie
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  NMR in biomedicine     Volume:  -     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Department of Biomedical Engineering, University of California, Davis, CA, USA. chqtu@ucdavis.edu.
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