Document Detail


Strategies for the development of gadolinium-based 'q'-activatable MRI contrast agents.
MedLine Citation:
PMID:  23015370     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The emergence and rapid development of activatable contrast agents (CAs), whose relaxivity changes in response to the variation of a specific marker in the surrounding physiological microenvironment, have expanded the scope of MRI beyond anatomical and functional imaging to also convey information at the cellular and molecular level. The essence of an activatable MRI CA is the difference in relaxivity before and after a change in a physiological variable: the larger the difference, the better the CA. In this review, strategies for the design of activatable gadolinium CAs, with a switching mechanism based on the modulation of hydration (q), sensitive to common variables in the physiological microenvironment, such as pH, light, redox and metal ions, are illustrated and discussed.
Authors:
Chuqiao Tu; Angelique Y Louie
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-09-27
Journal Detail:
Title:  NMR in biomedicine     Volume:  26     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-20     Completed Date:  2014-01-13     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  781-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Contrast Media / diagnostic use*
Gadolinium / diagnostic use*
Humans
Hydrogen-Ion Concentration
Light
Magnetic Resonance Imaging*
Oxidation-Reduction
Grant Support
ID/Acronym/Agency:
R01 EB000993/EB/NIBIB NIH HHS; R01 EB000993/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; AU0V1LM3JT/Gadolinium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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