Document Detail

Strategies for antenatal detection of Down's syndrome.
MedLine Citation:
PMID:  9059182     Owner:  NLM     Status:  MEDLINE    
AIM: To predict the effect of maternal serum screening and fetal echocardiography on the birth prevalence of Down's syndrome. METHODS: The outcome of all Down's syndrome pregnancies in the Northern Health Region between 1985 and 1991 was retrospectively ascertained. The number and outcome of all Down's syndrome pregnancies were used to define a theoretical population which would exist in the absence of screening. Published reports were used to predict the effects of screening strategies. RESULTS: Down's syndrome was identified in 412 pregnancies of which 315 (76%) resulted in live birth. A theoretical population with no antenatal screening would be expected to produce 31 stillbirths and 381 (92%) live births affected by Down's syndrome. In the same population a programme of maternal serum screening and fetal echocardiography would lead to 155 and 14 terminations, respectively, and when combined, would reduce affected live births to 229 (56%). CONCLUSIONS: Even if maternal serum screening and fetal echocardiography achieve their predicted potential, around half of all pregnancies affected by Down's syndrome will result in live born babies.
J P Wyllie; R J Madar; M Wright; J Burn; C Wren
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  76     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F26-30     Citation Subset:  AIM; IM    
Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne.
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MeSH Terms
Chorionic Gonadotropin / blood
Down Syndrome / diagnosis*,  epidemiology
England / epidemiology
Estriol / blood
Fetal Diseases / diagnosis*
Maternal Age
Pregnancy, High-Risk
Prenatal Diagnosis / methods*
Ultrasonography, Prenatal*
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol

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