Document Detail

Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction.
MedLine Citation:
PMID:  21818697     Owner:  NLM     Status:  MEDLINE    
Tissue-engineered cardiac constructs are a high potential therapy for treating myocardial infarction. These therapies have the ability to regenerate or recreate functional myocardium following the infarction, restoring some of the lost function of the heart and thereby preventing congestive heart failure. Three key factors to consider when developing engineered myocardial tissue include the cell source, the choice of scaffold, and the use of biomimetic culture conditions. This review details the various biomaterials and scaffold types that have been used to generate engineered myocardial tissues as well as a number of different methods used for the fabrication and culture of these constructs. Specific bioreactor design considerations for creating myocardial tissue equivalents in vitro, such as oxygen and nutrient delivery as well as physical stimulation, are also discussed. Lastly, a brief overview of some of the in vivo studies that have been conducted to date and their assessment of the functional benefit in repairing the injured heart with engineered myocardial tissue is provided.
Kathy Yuan Ye; Lauren Deems Black
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Publication Detail:
Type:  Comment; Journal Article; Review     Date:  2011-08-05
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  4     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2012-01-12     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-91     Citation Subset:  IM    
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MeSH Terms
Myocardial Infarction / therapy*
Myocardium / pathology*
Regenerative Medicine / methods*
Stem Cell Transplantation*
Tissue Engineering*
Grant Support
Comment On:
J Cardiovasc Transl Res. 2011 Oct;4(5):603-4   [PMID:  21833814 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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