Document Detail


Strategies for tissue engineering cardiac constructs to affect functional repair following myocardial infarction.
MedLine Citation:
PMID:  21818697     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue-engineered cardiac constructs are a high potential therapy for treating myocardial infarction. These therapies have the ability to regenerate or recreate functional myocardium following the infarction, restoring some of the lost function of the heart and thereby preventing congestive heart failure. Three key factors to consider when developing engineered myocardial tissue include the cell source, the choice of scaffold, and the use of biomimetic culture conditions. This review details the various biomaterials and scaffold types that have been used to generate engineered myocardial tissues as well as a number of different methods used for the fabrication and culture of these constructs. Specific bioreactor design considerations for creating myocardial tissue equivalents in vitro, such as oxygen and nutrient delivery as well as physical stimulation, are also discussed. Lastly, a brief overview of some of the in vivo studies that have been conducted to date and their assessment of the functional benefit in repairing the injured heart with engineered myocardial tissue is provided.
Authors:
Kathy Yuan Ye; Lauren Deems Black
Related Documents :
16230867 - Prevalence of symptomatic diastolic heart failure in patients hospitalized with cerebra...
18926007 - A sketch-based interface for modeling myocardial fiber orientation that considers the l...
15947277 - Therapy implications of transthoracic echocardiography in acute ischemic stroke patients.
7737247 - Parkinsonism in patients with lucanar infarcts of the basal ganglia.
22239627 - Recent developments on coronary microvasculopathy after heart transplantation: a new ta...
13708707 - The ultrastructure of cardiac desnosomes in the toad and their relationship to the inte...
Publication Detail:
Type:  Comment; Journal Article; Review     Date:  2011-08-05
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  4     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2012-01-12     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-91     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Tufts University, Medford, MA, USA. kathy.ye@tufts.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Myocardial Infarction / therapy*
Myocardium / pathology*
Regeneration*
Regenerative Medicine / methods*
Stem Cell Transplantation*
Tissue Engineering*
Grant Support
ID/Acronym/Agency:
R00 HL093358-03/HL/NHLBI NIH HHS; R00 HL093358-04/HL/NHLBI NIH HHS
Comments/Corrections
Comment On:
J Cardiovasc Transl Res. 2011 Oct;4(5):603-4   [PMID:  21833814 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of pre-test genetic counseling for deaf adults on knowledge of genetic testing.
Next Document:  Appropriateness of referrals for single-photon emission computed tomography myocardial perfusion ima...