Document Detail


Strategies for Designing and Validating Immunostimulatory siRNAs.
MedLine Citation:
PMID:  23027052     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Specific clinical applications of RNA interference (RNAi) can benefit from a concurrent activation of the immune system. This is the case for small interfering RNAs (siRNAs) with antitumor or antiviral activities. This chapter provides a brief overview of the strategies reported to date to design siRNAs with gene silencing and immune activating properties, as well as methods for the validation of immunostimulatory activities.
Authors:
Michael P Gantier
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  942     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-10-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-91     Citation Subset:  IM    
Affiliation:
Monash Institute of Medical Research, Monash University, Clayton, VIC, Australia, michael.gantier@monash.edu.
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