Document Detail

Strategic treatment of anovular dairy cows with GnRH.
MedLine Citation:
PMID:  18926565     Owner:  NLM     Status:  MEDLINE    
The primary objective was to evaluate fertility of anovular dairy cows given GnRH 4 d after first postpartum timed AI (TAI). Secondary objectives were to determine ovulatory response to treatment, effect of treatment on serum progesterone (P(4)) concentrations, and the proportion with a short luteal phase. Lactating Holstein cows (n=1047) were submitted for first postpartum TAI using a Presynch+Ovsynch protocol. Anovular cows were identified from an initial 1047 lactating Holstein cows using transrectal ultrasonography, based on the absence of a CL at the first GnRH injection of a Presynch+Ovsynch protocol, and anovular cows were randomly assigned to receive either no further treatment (Control, n=85), or 100 microg of GnRH 4 d after TAI (GnRH treated; n=71). For GnRH treated cows, 51% responded by ovulating a follicle in response to GnRH treatment 4 d after TAI; however, pregnancies per AI (P/AI) did not differ between GnRH treated cows that ovulated (36%) compared to GnRH treated cows that did not ovulate (21%). There was a quadratic effect of P(4) at the PGF(2 alpha) injection of Ovsynch on P/AI, and cows with P(4)>or=1 ng/mL at the PGF(2 alpha) injection of Ovsynch had greater P/AI (41%) than cows with P(4)<1 ng/mL (12%); however, no treatment difference was detected. Overall, P/AI did not differ between control (30.1%) and GnRH treated (29.6%) treatments for synchronized cows. Although treatment of anovular cows with GnRH 4 d after TAI failed to improve fertility, variation among cows in serum P(4) at the PGF(2 alpha) injection of Ovsynch dramatically affected fertility of anovular dairy cows.
R A Sterry; E Silva; D Kolb; P M Fricke
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-10-15
Journal Detail:
Title:  Theriogenology     Volume:  71     ISSN:  0093-691X     ISO Abbreviation:  Theriogenology     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2008-12-30     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  534-42     Citation Subset:  IM    
Department of Dairy Science, University of Wisconsin, Madison, WI 53706, United States.
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MeSH Terms
Anovulation / veterinary*
Estrus Synchronization / drug effects
Fertility Agents, Female / administration & dosage*,  pharmacology*
Gonadotropin-Releasing Hormone / administration & dosage*,  pharmacology*
Insemination, Artificial / veterinary
Ovulation / drug effects
Progesterone / blood
Reg. No./Substance:
0/Fertility Agents, Female; 33515-09-2/Gonadotropin-Releasing Hormone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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