Document Detail


Strategic expression of ion transport peptide gene products in central and peripheral neurons of insects.
MedLine Citation:
PMID:  17111378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Structurally related ion transport peptides (ITP) and crustacean hyperglycemic hormones (CHH) are increasingly implicated in diverse metabolic and developmental functions in arthropods. We identified a conserved ITP gene encoding two peptides by alternative splicing in Manduca sexta, Bombyx mori, and Aedes aegypti: A C-terminally amidated ITP and a C-terminally unblocked ITP-like peptide (ITPL), which share common N-terminal sequences but have divergent C-termini. In the moth M. sexta, these peptides are expressed in two, regionally distinct neuronal populations in the central and peripheral nervous systems (CNS, PNS). MasITP expression is confined to the brain in five pairs of lateral neurosecretory cells (type Ia(2)) projecting ipsilateral axons into the retrocerebral complex and three to five pairs of adjacent small neurons that arborize extensively within the brain. Expression of MasITPL is comparatively weak in the brain but strong in the ventral ganglia and the PNS, where MasITP is absent. MasITPL occurs in bilaterally paired neurons of all thoracic and abdominal ganglia. In the PNS, MasITPL is coexpressed with crustacean cardioactive peptide in type II link nerve neurons (L1) of abdominal segments 2-7, which project axons into neurohemal transverse nerves. During metamorphosis, additional expression of MasITPL is observed in two pairs of small lateral neurons in the brain and one pair of ventromedial neurons in each of AG2-6. A similar pattern of differential ITP and ITPL expression was observed in the CNS and PNS of B. mori and Schistocerca americana. These distinctive cellular expression patterns suggest that ITP and ITPL have evolved specialized physiological functions in arthropods.
Authors:
Li Dai; Dusan Zitnan; Michael E Adams
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  500     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-11-23     Completed Date:  2007-02-01     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-67     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Affiliation:
Department of Entomology, University of California, Riverside, California 92521, USA.
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MeSH Terms
Descriptor/Qualifier:
Aedes / cytology
Alternative Splicing / genetics
Amino Acid Sequence
Animals
Axons / metabolism,  ultrastructure
Base Sequence
Bombyx / cytology,  genetics,  metabolism
Brain / cytology,  metabolism
Central Nervous System / cytology,  metabolism*
Ganglia, Invertebrate / cytology,  metabolism
Gene Expression Regulation / physiology
Immunohistochemistry
Insect Proteins / genetics,  metabolism*
Insects / cytology,  genetics*,  metabolism*
Manduca / cytology,  genetics,  metabolism
Molecular Sequence Data
Neuropeptides / genetics,  metabolism*
Neurosecretory Systems / cytology,  metabolism
Peripheral Nervous System / cytology,  metabolism*
Phylogeny
Protein Isoforms / genetics,  metabolism
Sequence Homology, Amino Acid
Species Specificity
Grant Support
ID/Acronym/Agency:
GM67310/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Insect Proteins; 0/Neuropeptides; 0/Protein Isoforms; 0/crustacean cardioactive peptide; 0/ion-transport peptide, Schistocerca gregaria

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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